Our previous transmission electron microscope and biochemical studies showed considerable regression of in utero induced galactose cataracts in rats following birth. The ultrastructural and biochemical alterations of the lens associated with such cataracts regressed considerably within a few days following birth. This report describes scanning electron microscope (SEM) observations made on lenses of offsprings of galactose-fed mothers. Lenses of rats delivered by galactose-fed mothers exhibited mature cataracts at birth. With SEM these lenses showed the presence of intercellular cysts, abnormal configuration, conformation and fragmentation of lens fibers. These changes were extensive at birth in the major portion of the lens, however, they became less extensive and gradually reduced in severity as the animal grew. By 28 days after parturition, lenses appeared normal and their morphology was comparable to that observed in lenses of offsprings from lab chow-fed animals. A probable mechanism(s) for the reestablishment of lens transparency is discussed.

Keywords:
Scanning electron microscopy, In utero cataracts, Galactose cataracts, Cataract reversal, lens fiber cells, lens morphology
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© 1981 S. Karger AG, Basel
1981
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