Intravitreal injection of Toxocara canis and Ascaris suum larvae into guinea pigs is being studied as a model for human ocular toxocariasis. IgE antibody-mediated mechanisms may be of importance in the ocular immunopathologic reaction to ascarid parasites. Intravitreal injection of second and fourth stage A. suum larvae, second stage T. canis larvae, or a soluble antigen obtained from cultures in defined media of third stage A. suum molting to the fourth stage (ACF antigen) was followed by the appearance of IgE antibody in aqueous humor and serum, detectable by the 6-day passive cutaneous anaphylactic (P-K) test. Animals systemically immunized to the ACF antigen and possessing serum IgE antibody titers of 1:1,000 to 1:10,000 had little or no IgE antibody in their aqueous humor. The ability of soluble antigens to provoke systemic and intraocular IgE antibody responses suggests that antigens released by living larvae may be important in this process. The observation that intraocular IgE antibodies occur in some animals lacking detectable serum IgE antibody indicates that the intraocular IgE antibody is locally produced.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.