Glycogen synthetase activity in the rabbit cornea was studied electron histochemically with an enzyme synthetic method using glycogen synthetase. Polyglucose particles synthesized from uridine diphosphate glucose by glycogen synthetase were located in the corneal epithelium, mainly in the superficial half of the epithelium. These particles were 130–290 Å in diameter. This result suggests that glycogen synthesis occurs mainly in the superficial half of the epithelium. On the other hand, judging from the fact that phosphorylase is located in the corneal epithelium, mainly in the deep layer, glycogen may usually be broken down and carbohydrate metabolism including glucose from aqueous humor may be done in the deep layer, especially in the basal cell which contains rich cytoplasmic organelles. Thus, synthesis and degradation of glycogen in the cornea may be related to the architecture of the epithelium.

Keywords:
Rabbit, Cornea, Glycogen synthetase, Glycogen metabolism, Electron microscopic histochemistry, Glycogen, Corneal epithelium
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© 1978 S. Karger AG, Basel
1978
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