The effect of p-chloromercuribenzene sulfonate (PCMBS) on the lens cation transport system was studied. PCMBS was used since this reagent has been reported to act primarily on the sulfhydryl (-SH) groups of the surface membranes. In this study, PCMBS was found to decrease the accumulation of labeled rubidium ions in rat lens. Under certain conditions, PCMBS affects the rubidium accumulation without affecting the levels of reduced glutathione or adenosine triphosphate indicating that the reagent did not enter the lens fibers. These observations thus further support the idea that -SH groups in the lens membranes do influence the cation transport mechanism.

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