... c release from the mitochondria into the cytosol [ 38 ]. The release of cytochrome c from the mitochondria is also regulated by proteins of the B-cell lymphoma 2 (Bcl-2) family. The Bcl-2 family is divided into two classes of molecules that have opposing effects: antiapoptotic members such as Bcl-2...

... mitochondrial lipid metabolism, may improve and subsequently stabilize visual functions, and it may also improve fundus alterations in patients affected by early AMD. Age-related macular degeneration Acetyl- L -carnitine n-3 fatty acids Coenzyme Q10 Mitochondria Clinical trial Visual field Visual...

...J. Feher; A. Papale; G. Mannino; L. Gualdi; C. Balacco Gabrieli Recent histopathologic studies have shown that mitochondria and peroxisomes of the retinal pigment epithelium may play a central role in the pathophysiology of age-related macular degeneration (AMD). We supposed that compounds which...

... and nt-14484 are called primary, because their association with LHON seems pathogenic. Other, secondary mutations have been associated with LHON, but their significance remains unclear [ 1, 8 ]. Multiple sclerosis Leber’s hereditary optic neuropathy Mitochondria Mitochondrial DNA 1999...