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Keywords: Age-related macular degenerationClose
Published Online: 07 October 2023
...Damla Oncel; Deniz Oncel; Kapil Mishra; Murat Oncel; J. Fernando Arevalo Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss among individuals aged 65 years and older in the USA. For individuals diagnosed with AMD, approximately 12% experience varying levels...
Merlin Dähmcke, Martin Busch, Johanna M. Pfeil, Tara Brauckmann, Daniel Schulz, Wael Omran, Ewa Morawiec-Kisiel, Fabienne Wähler, Sebastian Paul, Allam Tayar, Marie-Christine Bründer, Bastian Grundel, Andreas Stahl
Ophthalmologica (2023) 246 (3-4): 227–237.
Published Online: 09 August 2023
...-associated retinal diseases such as age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinal vein occlusion compared with control patients. Results: In serum samples, miR-29a-3p and miR-192-5p showed increased expression in patients with neovascular AMD relative to control patients...
Ophthalmologica (2023) 246 (2): 123–130.
Published Online: 18 July 2023
... in neovascular age-related macular degeneration (nAMD). This post hoc analysis of the CANTREAT trial explores the relationship between the maximal extension interval tolerated by patients receiving T&E ranibizumab and visual acuity outcomes. Methods: Treatment-naïve patients with nAMD were randomized...
Kenny Kodaday, Laurent Kodjikian, Etienne Gadiollet, Nicolas Chirpaz, Olivier Loria, Audrey Feldman, Flore De Bats, Carole Burillon, Philippe Denis, Pierre Pradat, Thibaud Mathis
Ophthalmologica (2023) 246 (2): 113–122.
Published Online: 18 July 2023
... nata or treat-and-extend [TAE]), according to macular neovascularization (MNV) subtype, on the functional and anatomical response in neovascular age-related macular degeneration (nAMD). The secondary objective was to compare the treatment burden between each MNV subtype. Methods: Consecutive treatment...
Andrea Scupola, Matteo Mario Carlà, Francesco Boselli, Federico Giannuzzi, Alessandro De Filippis, Claudia Fossataro, Angelo Maria Minnella, Guglielmo D'Amico, Giovanni Coppola, Maria Cristina Savastano, Maria Grazia Sammarco, Stanislao Rizzo
Ophthalmologica (2023) 246 (1): 58–67.
Published Online: 09 May 2023
... the early efficacy and safety of treatment with intravitreal injections (IVIs) of brolucizumab in patients presenting with neovascular age-related macular degeneration (nAMD) in a real-world setting. Methods: This retrospective study included 194 eyes of 180 patients with nAMD treated with standard 6-mg...
Rodrigo Vilares-Morgado, Ivo Silva, Ana Maria Cunha, Ângela Carneiro, Fernando Falcão-Reis, Manuel Falcão
Ophthalmologica (2022) 245 (6): 528–537.
Published Online: 19 July 2022
... Retinal pigment epithelium and outer retinal atrophy Age-related macular degeneration Dry age-related macular degeneration Exudative age-related macular degeneration Non-exudative macular neovascularization Age-related macular degeneration (AMD) is a degenerative disease that affects...
Carl Regillo, Rishi Singh, Robin Hamilton, Kinfemichael Gedif, Catherine Best, Adrian Koh, Frank G. Holz
Ophthalmologica (2022) 245 (5): 403–412.
Published Online: 25 April 2022
...Carl Regillo; Rishi Singh; Robin Hamilton; Kinfemichael Gedif; Catherine Best; Adrian Koh; Frank G. Holz Introduction: Neovascular age-related macular degeneration (nAMD) is characterized by exudation of fluid from abnormally growing blood vessels in the macula. Anti-vascular endothelial growth...
Ophthalmologica (2022) 245 (4): 385–392.
Published Online: 03 February 2022
...Dana Zvi; Dinah Zur; Shula Schwartz; Shai Cohen; Avi Saranga; Anat Loewenstein; Michaella Goldstein Introduction: The increasing high prevalence of neovascular age-related macular degeneration (nvAMD) in the aging population combined with the need for frequent monitoring and treatment for many...
Ophthalmologica (2022) 245 (3): 195–203.
Published Online: 11 January 2022
...Thomas Richard Johansen Forshaw; Yousif Subhi; Sten Andréasson; Torben Lykke Sørensen Background: The aim of this study was to systematically review the literature and to perform meta-analyses on full-field electroretinography (ffERG) between healthy controls and age-related macular degeneration...
Gilad Rabina, Anfisa Ayalon, Michael Mimouni, Nir Stanescu, Elad Moisseiev, Arie Y. Nemet, Noa Geffen, Ori Segal
Ophthalmologica (2022) 245 (4): 342–349.
Published Online: 22 November 2021
... bevacizumab (IVB) injections for age-related macular degeneration (AMD) patients with peripapillary choroidal neovascularization (PPCNV). Methods: The study involved a retrospective case series of consecutive patients diagnosed with PPCNV secondary to AMD. All patients were treated with IVB injections...
Ophthalmologica (2022) 245 (3): 204–217.
Published Online: 25 October 2021
...Alexander Foss; Tryfon Rotsos; Theo Empeslidis; Victor Chong Age-related macular degeneration (AMD) is a leading cause of blindness. Late AMD can be classified into exudative (commonly known as wet AMD [wAMD]) or dry AMD, both of which may progress to macular atrophy (MA). MA causes irreversible...
Charlotte De Sutter, Pieter-Paul Schauwvlieghe, Joke Ruys, Ine Cosemans, Jozef Depla, Sven Van Laere, Marc Veckeneer
Ophthalmologica (2022) 245 (1): 69–79.
Published Online: 16 September 2021
... for RPE-choroid TS included complications of neovascular age-related macular degeneration in 34 patients and drusenoid pigment epithelial detachment in 2 patients. With a mean follow-up of 30 months, 8 patients out of 36 developed signs of MNV. Of these 8 patients, 4 presented with a drop in visual acuity...
Costanza Barresi, Enrico Borrelli, Federico Fantaguzzi, Domenico Grosso, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques
Ophthalmologica (2021) 244 (6): 512–522.
Published Online: 13 September 2021
...Costanza Barresi; Enrico Borrelli; Federico Fantaguzzi; Domenico Grosso; Riccardo Sacconi; Francesco Bandello; Giuseppe Querques Background: Neovascular age-related macular degeneration (AMD) represents a leading cause of vision loss in older subjects. The introduction of anti-vascular endothelial...
Tomohiro Nizawa, Masayasu Kitahashi, Takayuki Baba, Takehito Iwase, Mariko Kubota-Taniai, Yoko Hattori, Yuki Shiko, Yohei Kawasaki, Takayuki Iwase, Takatoshi Sato, Shoko Ogawa, Takeshi Sugawara, Shuichi Yamamoto
Ophthalmologica (2021) 244 (4): 347–360.
Published Online: 07 September 2021
... sensitivity (MS) of the central retina, best-corrected visual acuity (BCVA), and central foveal thickness (CFT) in eyes with neovascular age-related macular degeneration (nAMD) with or without polypoidal choroidal vasculopathy (PCV). Methods: This was a prospective, interventional study. All eyes were...
Ophthalmologica (2021) 244 (3): 173–178.
Published Online: 06 July 2021
...Athanasios Zisimopoulos; Olga Klavdianou; Panagiotis Theodossiadis; Irini Chatziralli Background: Age-related macular degeneration (AMD) is a progressive, multifactorial, degenerative disease and the leading cause of severe visual loss in the elderly population. The exact pathogenesis of AMD...
Steffen Schmitz-Valckenberg, Martina D. Braun, Sarah Thiele, Daniela Ferrara, Lee Honigberg, Simon S. Gao, Hao Chen, Verena Steffen, Frank G. Holz, Marlene Saßmannshausen
Ophthalmologica (2021) 244 (6): 523–534.
Published Online: 25 June 2021
... intermediate age-related macular degeneration (iAMD) subcohort using high-resolution multimodal imaging anchored on optical coherence tomography (OCT). Methods: Thirty-two patients from the Proxima B iAMD subcohort were assessed; all had GA with no macular neovascularization (MNV) in the contralateral eye...
Ophthalmologica (2021) 244 (6): 495–511.
Published Online: 15 June 2021
...Rita Flores; Ângela Carneiro; Miguel Vieira; Sandra Tenreiro; Miguel C. Seabra Among older adults, age-related macular degeneration (AMD) is a prevalent disabling condition that begins as subtle visual disturbances and can progress to permanent loss of central vision. In its late neovascular form...
Sophie Beka, Rupert Wolfgang Strauss, Dominika Podkowinski, Anna Sophie Mursch-Edlmayr, Siegfried Mariacher, Anna-Sophie Hofer, Matthias Bolz
Ophthalmologica (2022) 245 (1): 10–18.
Published Online: 03 June 2021
...Sophie Beka; Rupert Wolfgang Strauss; Dominika Podkowinski; Anna Sophie Mursch-Edlmayr; Siegfried Mariacher; Anna-Sophie Hofer; Matthias Bolz Purpose: The aim of the study was to examine real-world data of patients with neovascular age-related macular degeneration (nAMD) within a disease management...
Ophthalmologica (2021) 244 (3): 200–207.
Published Online: 19 January 2021
...Sankha Amarakoon; Jose P. Martinez-Ciriano; Seerp Baarsma; L. Ingeborgh van den Born; Tom Missotten Introduction: Treatment of exudative age-related macular degeneration (ARMD) has shifted to pro re nata and treat-extend-stop strategies. However, a rational discontinuation strategy is lacking...
Jan Henrik Terheyden, Steffen Schmitz-Valckenberg, David P. Crabb, Hannah Dunbar, Ulrich F.O. Luhmann, Charlotte Behning, Matthias Schmid, Rufino Silva, José Cunha-Vaz, Adnan Tufail, Georges Weissgerber, Sergio Leal, Frank G. Holz, Robert P. Finger, on behalf of the MACUSTAR Consortium
Ophthalmologica (2021) 244 (5): 387–395.
Published Online: 07 December 2020
... progression of early age-related macular degeneration (AMD) stages to advanced AMD requires the use of surrogate end points in clinical trials. The use of combined end points may allow for shorter and smaller trials due to increased precision. We performed a literature search for the use of composite end...