Introduction: To compare visual outcomes and complication rates of giant retinal tear-associated retinal detachment (GRT-RD) cases treated with short-term perfluorodecalin (PFD) tamponade versus silicone oil (SiO). Methods: Database analysis of patients with GRT-RD operated on in the period from 1 January 2014 to 31 December 2019. Results: Forty-five patients were operated for GRT-RD using PFD or SiO during this period. Two children, 7 patients receiving gas tamponade, and 2 lost to follow-up were excluded. Eighteen eyes (40%) received PFD and 27 (60%) received SiO. There were 15/18 (83%) macula-sparing cases in the PFD group and 18/27 (67%) in the SiO group (p = 0.13). The mean duration of oil tamponade was 91 days for SiO and 7.6 days for PFD (p < 0.0001). The mean length of follow-up was 274.5 days for PFD and 668.9 days for SiO. The mean BCVA was 6/18 (63.4 ± 26.0 ETDRS letters) for SiO and 6/12 (72.9 ± 12.7 ETDRS letters) for PFD (p = 0.42). Analysing macula-sparing pseudophakic eyes, the BCVA was 6/12 (67.4 ± 25.9 letters, n = 18) for SiO eyes and 6/9 (76.8 ± 9.9 letters, n = 11) for PFD eyes (p = 0.54). The recurrence rate was 22% (6/27) for SiO and 6% (1/18) for PFD (p = 0.12). The rate of cystoid macular oedema (CMO) was 22% for SiO and 22% for PFD. Epiretinal membrane (ERM) was found in 26% of SiO cases and 22% of PFD cases. Loss of vision after oil removal was not observed. Seven eyes (26%) receiving SiO and none receiving PFD developed chronic ocular hypertension (OHT) (p = 0.02). Conclusions: Short-term tamponade with PFD for GRT-RD appears similar to tamponade with SiO in terms of the visual outcomes and complication rates.

1.
Shunmugam
M
,
Ang
GS
,
Lois
N
.
Giant retinal tears
.
Surv Ophthalmol
.
2014
Mar-Apr
;
59
(
2
):
192
216
.
[PubMed]
0039-6257
2.
Ang
GS
,
Townend
J
,
Lois
N
.
Epidemiology of giant retinal tears in the United Kingdom: the British Giant Retinal Tear Epidemiology Eye Study (BGEES)
.
Invest Ophthalmol Vis Sci
.
2010
Sep
;
51
(
9
):
4781
7
.
[PubMed]
0146-0404
3.
Camacho
H
,
Bajaire
B
,
Mejia
LF
.
Silicone oil in the management of giant retinal tears
.
Ann Ophthalmol
.
1992
Feb
;
24
(
2
):
45
9
.
[PubMed]
0003-4886
4.
Chang
S
,
Lincoff
H
,
Zimmerman
NJ
,
Fuchs
W
.
Giant retinal tears.
Surgical techniques and results using perfluorocarbon liquids. Arch Ophthalmol Chic Ill
1960
. 1989 May;107(5):761–6.
5.
Moya
R
,
Chandra
A
,
Banerjee
PJ
,
Tsouris
D
,
Ahmad
N
,
Charteris
DG
.
The incidence of unexplained visual loss following removal of silicone oil
.
Eye (Lond)
.
2015
Nov
;
29
(
11
):
1477
82
.
[PubMed]
0950-222X
6.
Banerjee
PJ
,
Chandra
A
,
Petrou
P
,
Charteris
DG
.
Silicone oil versus gas tamponade for giant retinal tear-associated fovea-sparing retinal detachment: a comparison of outcome
.
Eye (Lond)
.
2017
Sep
;
31
(
9
):
1302
7
.
[PubMed]
0950-222X
7.
Bottoni
F
,
Bailo
G
,
Arpa
P
,
Prussiani
A
,
Monticelli
M
,
de Molfetta
V
.
Management of giant retinal tears using perfluorodecalin as a postoperative short-term vitreoretinal tamponade: a long-term follow-up study
.
Ophthalmic Surg
.
1994
Jun
;
25
(
6
):
365
73
.
[PubMed]
0022-023X
8.
Sheridan
AM
,
Essex
RW
,
Yeoh
J
,
Allen
P
,
Campbell
WG
,
Edwards
TL
.
Is post-operative perfluorocarbon liquid tamponade for macula-on giant retinal tear safer than silicone oil?
Eye (Lond)
.
2019
Apr
;
33
(
4
):
689
91
.
[PubMed]
0950-222X
9.
Mikhail
MA
,
Mangioris
G
,
Best
RM
,
McGimpsey
S
,
Chan
WC
.
Management of giant retinal tears with vitrectomy and perfluorocarbon liquid postoperatively as a short-term tamponade
.
Eye (Lond)
.
2017
Sep
;
31
(
9
):
1290
5
.
[PubMed]
0950-222X
10.
Rush
R
,
Sheth
S
,
Surka
S
,
Ho
I
,
Gregory-Roberts
J
.
Postoperative perfluoro-N-octane tamponade for primary retinal detachment repair
.
Retina
.
2012
Jun
;
32
(
6
):
1114
20
.
[PubMed]
0275-004X
11.
Ventura
MC
,
Melo
C
,
Escarião
P
,
Diniz
JR
,
Leão
AC
.
[Perfluoroctane liquid as a short-term vitreous-retinal tamponade in the postoperative period in patients with retinal detachment due to giant tears]
.
Arq Bras Oftalmol
.
2007
May-Jun
;
70
(
3
):
495
500
.
[PubMed]
0004-2749
12.
Eiger-Moscovich
M
,
Gershoni
A
,
Axer-Siegel
R
,
Weinberger
D
,
Ehrlich
R
.
Short-Term Vitreoretinal Tamponade with Heavy Liquid Following Surgery for Giant Retinal Tear
.
Curr Eye Res
.
2017
Jul
;
42
(
7
):
1074
8
.
[PubMed]
0271-3683
13.
Randolph
JC
,
Diaz
RI
,
Sigler
EJ
,
Calzada
JI
,
Charles
S
.
25-gauge pars plana vitrectomy with medium-term postoperative perfluoro-n-octane for the repair of giant retinal tears
.
Graefes Arch Clin Exp Ophthalmol
.
2016
Feb
;
254
(
2
):
253
7
.
[PubMed]
0721-832X
14.
Rofail
M
,
Lee
LR
.
Perfluoro-n-octane as a postoperative vitreoretinal tamponade in the management of giant retinal tears
.
Retina
.
2005
Oct-Nov
;
25
(
7
):
897
901
.
[PubMed]
0275-004X
15.
Sirimaharaj
M
,
Balachandran
C
,
Chan
WC
,
Hunyor
AP
,
Chang
AA
,
Gregory-Roberts
J
, et al
Vitrectomy with short term postoperative tamponade using perfluorocarbon liquid for giant retinal tears
.
Br J Ophthalmol
.
2005
Sep
;
89
(
9
):
1176
9
.
[PubMed]
0007-1161
16.
Zhang
Z
,
Wei
Y
,
Jiang
X
,
Zhang
S
.
Surgical outcomes of 27-gauge pars plana vitrectomy with short-term postoperative tamponade of perfluorocarbon liquid for repair of giant retinal tears
.
Int Ophthalmol
.
2018
Aug
;
38
(
4
):
1505
13
.
[PubMed]
0165-5701
17.
_.
2018
-asrs-pat-survey-results-for-website-1.pdf [Internet]. [cited 2020 Jun 11]. Available from: https://www.asrs.org/content/documents/_2018-asrs-pat-survey-results-for-website-1.pdf
18.
Figueroa
MS
,
Casas
DR
.
Inflammation induced by perfluorocarbon liquid: intra- and postoperative use
.
BioMed Res Int
.
2014
;
2014
:
907816
.
[PubMed]
2314-6133
19.
Miller
JB
,
Papakostas
TD
,
Vavvas
DG
.
Complications of emulsified silicone oil after retinal detachment repair
.
Semin Ophthalmol
.
2014
Sep-Nov
;
29
(
5-6
):
312
8
.
[PubMed]
0882-0538
20.
Yang
JY
,
Kim
HK
,
Kim
SH
,
Kim
SS
.
Incidence and Risk Factors of Cystoid Macular Edema after Vitrectomy with Silicone Oil Tamponade for Retinal Detachment
.
Korean J Ophthalmol
.
2018
Jun
;
32
(
3
):
204
10
.
[PubMed]
1011-8942
21.
Banker
TP
,
Reilly
GS
,
Jalaj
S
,
Weichel
ED
.
Epiretinal membrane and cystoid macular edema after retinal detachment repair with small-gauge pars plana vitrectomy
.
Eur J Ophthalmol
.
2015
Nov-Dec
;
25
(
6
):
565
70
.
[PubMed]
1120-6721
22.
Romano
MR
,
Ferrara
M
,
Gatto
C
,
Ferrari
B
,
Giurgola
L
,
D’Amato Tóthová
J
.
Evaluation of Cytotoxicity of Perfluorocarbons for Intraocular Use by Cytotoxicity Test In Vitro in Cell Lines and Human Donor Retina Ex Vivo
.
Transl Vis Sci Technol
.
2019
Oct
;
8
(
5
):
24
.
[PubMed]
2164-2591
23.
Pastor
JC
,
Coco
RM
,
Fernandez-Bueno
I
,
Alonso-Alonso
ML
,
Medina
J
,
Sanz-Arranz
A
, et al
ACUTE RETINAL DAMAGE AFTER USING A TOXIC PERFLUORO-OCTANE FOR VITREO-RETINAL SURGERY
.
Retina
.
2017
Jun
;
37
(
6
):
1140
51
.
[PubMed]
0275-004X
24.
Off-label use of a medical device [Internet]. GOV.UK. [cited 2020 Jun 11]. Available from: https://www.gov.uk/government/publications/medical-devices-off-label-use/off-label-use-of-a-medical-device
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