Aim: To determine the efficacy and safety of Artisan phakic intraocular lenses (IOLs) for refractive error correction. Methods: A prospective study was conducted on patients undergoing Artisan phakic IOL implantation for myopia, hyperopia or astigmatism from 2002 to 2008. Visual acuity, manifest refractive spherical equivalent (MRSE), endothelial cell counts and higher order aberrations were recorded pre- and postoperatively. Results: One hundred and fifty-one (84 patients) myopic (mean MRSE –11.2 ± 4.1 D) and 14 (7 patients) hyperopic eyes (mean MRSE 7.1 ± 1.3 D) were treated. Twenty eyes (11 patients) had toric IOLs to correct astigmatism (mean MRSE –9.05 ± 6.13 D, mean astigmatism 4.06 ± 1.26 D). Three months postoperatively, mean MRSE in 37.6% of eyes was within ±0.5 D, 61.8% within ±1.0 D and 91.4% within ±2.0 D. 18.5% underwent keratorefractive surgery to correct residual refractive error. A 1.56-fold increase occurred in 4th order spherical aberration. Endothelial cell loss was 1.45% at 1 year and negligible at 5 years. Fifty-four eyes (29.2%) gained one or more lines of best corrected visual acuity and no eye lost a line. Conclusion: Artisan phakic IOLs are safe and effective for refractive error correction.

1.
Fechner PU, van der Heijde GL, Worst JG: The correction of myopia by lens implantation into phakic eyes. Am J Ophthalmol 1989;107:659–663.
2.
Fechner PU: Iris claw lens. Klin Monatsbl Augenheilkd 1987;191:26–29.
3.
Landesz M, Worst JG, Siertsema JV, van Rij G: Correction of high myopia with the Worst myopia claw intraocular lens. J Refract Surg 1995;11:16–25.
4.
Alió JL, Mulet ME, Gutierrez R, Galal A: Artisan toric phakic intraocular lens for correction of astigmatism. J Refract Surg 2005;21:324–331.
5.
Coullet J, Güell JL, Fournie P, Grandjean H, Gaytan J, Arne JL, Malecaze F: Iris-supported phakic lenses (rigid vs. foldable version) for treating moderately high myopia: randomized paired eye comparison. Am J Ophthalmol 2006;142:909–916.
6.
Menezo JL, Peris-Martinez C, Cisneros AL, Martinez-Costa R: Phakic intraocular lenses to correct high myopia: Adatomed, Staar and Artisan. J Cataract Refract Surg 2004;30:33–44.
7.
Tahzib NG, Nuijts RM, Wu WY, Budo CJ: Long-term study of Artisan phakic intraocular lens implantation for the correction of moderate to high myopia: ten-year follow- up results. Ophthalmology 2007;114:1133–1142.
8.
Pop M, Payette Y: Initial results of endothelial cell counts after Artisan lens for phakic eyes: an evaluation of the United States Food and Drug Administration Ophtec Study. Ophthalmology 2004;111:309–317.
9.
Benedetti S, Casamenti V, Marcaccio L, Brogioni C, Assetto V: Correction of myopia of 7 to 24 diopters with the Artisan phakic intraocular lens: two-year follow-up. J Refract Surg 2005;21:116–126.
10.
Alió JL, Mulet ME, Shalaby AM: Artisan phakic iris claw intraocular lens for high primary and secondary hyperopia. J Refract Surg 2002;18:697–707.
11.
Munoz G, Alió JL, Montes-Mico R, Albarran-Diego C, Belda JI: Artisan iris claw phakic intraocular lens followed by laser in situ keratomileusis for high hyperopia. J Cataract Refract Surg 2005;31:308–317.
12.
Saxena R, Landesz M, Noordzij B, Luyten GP: Three-year follow-up of the Artisan phakic intraocular lens for hypermetropia. Ophthalmology 2003;110:1391–1395.
13.
Güell JL, Morral M, Gris O, Gaytan J, Sisquella M, Manero F: Five-year follow-up of 399 phakic Artisan-Verisyse implantation for myopia, hyperopia, and/or astigmatism. Ophthalmology 2008;115:1002–1012.
14.
Stulting RD, John ME, Maloney RK, Assil KK, Arrowsmith PN, Thompson VM; U.S. Verisyse Study Group: Three-year results of the United States Food and Drug Administration clinical trial. Ophthalmology 2008;115:464–472.
15.
Benedetti S, Casamenti V, Benedetti M: Long-term endothelial changes in phakic eyes after Artisan intraocular lens implantation to correct myopia: five-year study. J Cataract Refract Surg 2007;33:784–790.
16.
Budo C, Hessloehl JC, Izak M, Luyten GP, Menezo JL, Sener BA, Tassignon MJ, Termote H, Worst JG: Multicenter study of the Artisan phakic intraocular lens. J Cataract Refract Surg 2000;26:1163–1171.
17.
Maloney RK, Nguyen LH, John ME: Artisan phakic intraocular lens for myopia: short-term results of a prospective, multicentre study. Ophthalmology 2002;109:1631–1641.
18.
Vetrugno M, Cardascia N, Cardia L: Anterior chamber depth measured by two methods in myopic and hyperopic phakic IOL implant. Br J Ophthalmol 2000;84:1113–1116.
19.
Tahzib NG, Bootsma SJ, Eggink FA, Nuijts RM: Functional outcome and patient satisfaction after Artisan phakic intraocular lens implantation for the correction of myopia. Am J Ophthalmol 2006;142:31–39.
20.
Tahzib NG, MacRae SM, Yoon G, Berendschot TT, Eggink FA, Hendrikse F, Nuijts RM: Higher order aberrations after implantation of iris-fixated rigid or foldable phakic intraocular lenses. J Cataract Refract Surg 2008;34:1913–1920.
21.
Bühren J, Kasper T, Terzi E, Kohnen T: Higher order aberrations after implantation of an iris claw pIOL (Ophtec Artisan) in the phakic eye (in German). Ophthalmologe 2004;101:1194–1201.
22.
Kirwan C, O’Keefe M: Comparative study of higher order aberrations after conventional laser in situ keratomileusis and laser epithelial keratomileusis for myopia using the Technolas 217z laser platform. Am J Ophthalmol 2009;147:77–83.
23.
O’Brien TP, Awwad ST: Phakic intraocular lenses and refractory lensectomy for myopia. Curr Opin Ophthalmol 2002;13:264–270.
24.
Alió JL, de la Hoz F, Pérez-Santonja JJ, Ruiz-Moreno JM, Quesada JA: Phakic anterior chamber lenses for the correction of myopia: a 7-year cumulative analysis of complications in 263 cases. Ophthalmology 1999;106:458–466.
25.
Alió JL, Abdelrahman AM, Javaloy J, Iradier MT, Ortuno V: Angle-supported anterior chamber phakic intraocular lens explantation. Ophthalmology 2006;113:2213–2220.
26.
Ruiz-Moreno JM, Montero JA, de la Vega C, Alió JL, Zapater P: Retinal detachment in myopic eyes after phakic intraocular lens implantation. J Refract Surg 2006;22:247–252.
27.
Arne JL: Phakic intraocular lens implantation versus clear lens extraction in highly myopic eyes of 30- to 50-year-old patients. J Cataract Refract Surg 2004;30:2092–2096.
28.
Colin J, Robinet A, Cochener B: Retinal detachment after clear lens extraction for high myopia: seven-year follow-up. Ophthalmology 1999;106:2281–2284.
29.
Sanders DR: Anterior subcapsular opacities and cataracts 5 years after surgery in the Visian implantable collamer lens FDA trial. J Refract Surg 2008;24:566–570.
30.
Ruiz-Moreno JM, Montero JA, de la Vega C, Alió JL, Zapater P: Macular choroidal neovascularization in myopic eyes after phakic intraocular lens implantation. J Refract Surg 2006;22:689–694.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.