Purpose: To establish the protective efficacy against late complications of electron therapy using customized lead eye shields in cases with orbital and periorbital lesions. Methods: Between 1982 and 2006, 16 patients with 22 orbital and periorbital lesions were treated by electron therapy. Customized lead eye shields were prepared and placed in the respective patients’ eyes during each fraction of electron therapy. The toxicity and local control rates were analyzed. Results: The preparation period for the customized lead eye shields was 2 days. The shields could be used throughout the treatment period in all the patients. No evidence of radiation cataract was observed in 15 of the 16 patients. None of the patients developed corneal ulceration or evidence of lead poisoning. Conclusion: Customized lead eye shields could be made relatively quickly, and electron therapy for orbital and periorbital lesions could be undertaken safely without any late complication.

Keywords:
Lead eye shields, Electron therapy, Lymphoma, Neoplasm
1.
Asbell SO, Siu J, Lightfoot DA, Brady LW: Individualized eye shields for use in electron beam therapy as well as low-energy photon irradiation. Int J Radiat Oncol Biol Phys 1980;6:519–521.
2.
Jereb B, Lee H, Jakobiec FA, Kutcher J: Radiation therapy of conjunctival and orbital lymphoid tumors. Int J Radiat Oncol Biol Phys 1984;10:1013–1019.
3.
Smitt MC, Donaldson SS: Radiotherapy is successful treatment for orbital lymphoma. Int J Radiat Oncol Biol Phys 1993;26:59–66.
4.
Bhatia S, Paulino AC, Buatti JM, Mayr NA, Wen BC: Curative radiotherapy for primary orbital lymphoma. Int J Radiat Oncol Biol Phys 2002;54:818–823.
5.
Lee SW, Suh CO, Kim GE, Yang WI, Lee SY, Hahn JS, Park JO: Role of radiotherapy for primary orbital lymphoma. Am J Clin Oncol. 2002;25:261–265.
6.
Zhou P, Ng AK, Silver B, Li S, Hua L, Mauch PM: Radiation therapy for orbital lymphoma. Int J Radiat Oncol Biol Phys 2005;63:866–871.
7.
Suh CO, Shim SJ, Lee SW, Yand WI, Lee SY, Hahn JS: Orbital marginal zone B-cell lymphoma of MALT: radiotherapy results and clinical behavior. Int J Radiat Oncol Biol Phys 2006;65:228–233.
8.
Fitzpatrick PJ, Thompson GA, Easterbrook WM, Gallie BL, Payne DG: Basal and squamous cell carcinoma of the eyelids and their treatment by radiotherapy. Int J Radiat Oncol Biol Phys 1984;10:449–454.
9.
Kishi K, Shirai S, Sonomura T, Kawai N, Naya Y, Matsunaka M, Sato M, Yamada R: Lead contact lens for crystalline lens shielding in electron therapy for eyelid tumors. Radiat Med 1996;14:107–109.
10.
Austin-Seymour MM, Donaldson SS, Egbert PR, McDougall IR, Kriss JP: Radiotherapy of lymphoid diseases of the orbit. Int J Radiat Oncol Biol Phys 1985;11:371–379.
11.
Bessell EM, Henk JM, Wright JE, Whitelocke RA: Orbital and conjunctival lymphoma treatment and prognosis. Radiother Oncol 1988;13:237–244.
12.
Minehan KJ, Martenson JA, Garrity JA, Kurtin PJ, Banks PM, Chen MG, Earle JD: Local control and complications after radiation therapy for primary orbital lymphoma: a case for low-dose treatment. Int J Radiat Oncol Biol Phys 1991;20:791–796.
13.
Letschert JG, Gonzalez D, Oskam J, Koornneef L, van Dijk JD, Boukes R, Bras J, van Heerde P, Bartelink H: Results of radiotherapy in patients with stage I orbital non-Hodgkin’s lymphoma. Radiother Oncol 1991;22:36–44.
14.
Schlienger P, Brunin F, Desjardins L, Laurent M, Haye C, Vilcoq JR: External radiotherapy for carcinoma of the eyelid: Report of 850 cases treated. Int J Radiat Oncol Biol Phys 1996;34:277–287.
15.
Esik O, Ikeda H, Mukai K, Kaneko A: A retrospective analysis of different modalities for treatment of primary orbital non-Hodgkin’s lymphomas. Radiother Oncol 1996;38:13–18.
16.
Shimizu H (ed): Standard Ophthalmology, ed 7. Tokyo, Igaku-Shoin, 1998, pp 223–224.
17.
Weaver RD, Gerbi BJ, Dusenbery KE: Evaluation of eye shields made of tungsten and aluminum in high-energy electron beams. Int J Radiat Oncol Biol Phys 1998;41:233–237.
18.
Hashizume T, Taniguchi H, Inoue T, Oki M, Takeda M, Shibuya H, Ohyama T: Application of individual lead shield in radiotherapy of eyelid tumor. Maxillofacial Prosthetics 1999;22:34–40.
19.
Khan FM: The Physics of Radiation Therapy, ed 2. Baltimore, Williams & Wilkins, 1994.
20.
Merriam GR Jr, Szechter A, Focht EF: The effects of ionizing radiation on the eye. Front Radiat Ther Oncol 1972;6:346–385.
21.
Rubin R, Casarett G.W.: Clinical Radiation Pathology. New York, W.B. Saunders, 1968.
© 2008 S. Karger AG, Basel
2008
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.