A prospective randomized double-blind clinical study was performed to investigate corneal wound healing after treatment either with an eye gel containing calf blood extract or an eye ointment containing vitamin A and dexpanthenol. A total of 54 outpatients were included in this study, all treated for corneal foreign body injury. The size of the corneal lesions was measured by planimetry on days 0, 1, and on the following days until complete epithelial healing occurred. Results showed the calf blood extract eye gel to be statistically more effective in promoting corneal wound healing, especially in patients with wound areas larger than 6 mm2.

Erbe W, Herrmann R, Körner WF, Rohde-Germann H, Straub W: Our experience with Solcoseryl®-eye gel in the treatment of corneal lesions: A randomised double-blind study. Ophthalmologica 1984;188:1–4.
Menna F: Therapeutic effects in ocular lesions, obtained by systemic and topical administration of an activator of the oxygen metabolism. Ophthalmologica 1980;180(suppl 1):1–50.
Nemeth B, Bencsik R, Opauszki A: Therapeutische Erfahrungen mit einem Blutextrakt bei Kornealäsionen. Klin Monatsbl Augenheilkd 1981;178:390–391.
Haydon: Die Wirkung von Solcoseryl®-Augen-Gel in Kombination mit Neomycin und Bacitracin auf die Heilung von Hornhautläsionen nach Fremdkörperentfernung. Klin Monatsbl Augenheilkd 1983;183:213–215.
Nakamura M, Ofuji K, Chikama T, Nishida T: Combined effects of substance P and insulin-like growth factor-1 on corneal epithelial wound closure of rabbit in vivo. Curr Eye Res 1997;16:275–278.
Callizo J, Cervello I, Mayayo E, Mallol J: Corneal wound healing in rabbit eye: Activity of a fibronectin-splitting product. Cornea 1996;15:263–270.
Smolin G, Okumoto M: Vitamin A acid and corneal epithelial wound healing. Ann Ophthalmol 1981;13:563–566.
Ubels JL, Edelhauser HF, Austin KH: Healing of experimental corneal wounds treated with topically applied retinoids. Am J Ophthalmol 1983;95:353–358.
Göbbels M, Gross D: Klinische Studie zur Wirksamkeit eines dexpanthenolhaltigen Tränenersatzmittels (Siccaprotect®) bei der Behandlung trockener Augen. Klin Monatsbl Augenheilkd 1996;209:84–88.
Kastl PR, Rosenthal WN, Batlle I, Karcioglu Z: Topical vitamin A ointment increases healing of cataract incisions. Ann Ophthalmol 1987;19:175–177.
Haselmann G, Pufrich K, Haselmann H: Zur Behandlung von Epithelschäden der Cornea. Ophthalmologie 1952;6:29.
Jakob HM: Dexpanthenol. DAZ 1995;23:2102.
Spessotto P, Dri P, Baschong W, Mittenzwei H, Patriarca P: Effect of protein-free dialysate from calf blood on human monocyte differentiation in vitro. Arzneimittelforschung 1993;43:747–751.
Studer O: A comparative clinical study of Solcoseryl®-eye gel and cysteine eye-gel 2.4% in the treatment of foreign body injuries of the cornea. Ophthalmic Res 1984;16:179–184.
Kuniaka T, Senga Y, Senga H, Weiner M: Nature of enhanced mitochondrial oxidative metabolism by a calf blood extract. J Cell Physiol 1991;146:148–155.
Krannig HM, Rohde-Germann H, Straub W: Therapy of corneal erosions and ‘dry eye’ with Solcoseryl® and Vitasic® eye drops. Ophthalmologica 1989;199:100–105.
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