...Lamis Al Harby; Mandeep S. Sagoo; Roderick O’Day; Gordon Hay; Amit K. Arora; Pearse A. Keane; Victoria M.-L. Cohen; Bertil Damato Objective: The aim of this study was to determine the sensitivity and specificity of the MOLES scoring system in differentiating choroidal melanomas from nevi according...

...Pradeep Manchegowda; Arun D. Singh; Carol Shields; Swathi Kaliki; Parag Shah; Lingam Gopal; Pukhraj Rishi Despite limited data, some differences in the clinical profile can be observed in Asian population when compared with presentation of uveal melanoma (UM) in white population. The incidence...

... syndrome Eosinophilic cellulitis Ptosis Melanoma Wells syndrome is a rare inflammatory skin disease, with extremities, trunk, and facial region are the most commonly affected area. Wells syndrome has never been described in a solitary ophthalmological presentation in the absence...

...Aaron Yeung; Ogul E. Uner; Jill R. Wells; Hans E. Grossniklaus Aim: The aim of this study is to describe the clinical and pathologic features of corneal primary acquired melanosis (PAM) and melanoma. Methods: We describe 3 cases in total: two cases of corneal melanomas and 1 case of corneal PAM...

..., ovarian, and endometrial cancer. Moreover, ASA has been shown to abrogate various processes that contribute to tumor growth and progression. Objective: The aim of this study was to evaluate the effects of ASA on cutaneous melanoma (CM) and uveal melanoma (UM). Methods: Human CM and UM cells were treated...

.... Standardized echography showed a choroidal mass with low-to-medium internal reflectivity, pockets of very low reflectivity, positive angle kappa, and 1+ vascularity that were concerning for primary choroidal melanoma. Biopsy of the lesion was consistent with metastatic squamous cell carcinoma of the tonsil...

... × 8.8 mm in base and 8.7 mm in height. Since the diagnosis was not clear, a repeat FNAB for cytology and gene expression profiling was performed in case this lesion turned out to be a melanoma. Cytology at the time of plaque placement demonstrated numerous heavily pigmented melanophages and rare...

...Spencer T. Langevin; Eileen Chang; Tony J.C. Wang; Israel Deutsch; Marc Otten; Brian P. Marr Ocular melanocytosis has traditionally been associated with increased risk of developing uveal melanoma; however, rarely primary episcleral melanoma has been reported in the literature. Herein, we present...

...Aimi Toyama; W. Robert Bell; Alessio Giubellino; Faqian Li Uveal melanomas are typically described as having epithelial or spindled cell morphology; however, as is the nature of melanomas, the morphology of the malignant melanocytes can be varied. We describe a unique case of metastatic uveal...

... with oculocutaneous albinism. Methods: Retrospective small case series. Three eyes of 2 Asian patients with oculocutaneous albinism were included. Case 1 was a 54-year-old female who presented with juxtapapillary choroidal melanoma and underwent enucleation. Case 2 was a 39-year-old male with pigmented choroidal...

...Yombe Fonkeu; Nakul Singh; Brandy Hayden-Loreck; Arun D. Singh Aim: To develop an automated algorithm to quantify ultrasonographic A-scan parameters of choroidal melanoma. Methods: The study included 100 consecutive patients with a clinical diagnosis of choroidal melanoma. Ultrasonographic A-scans...

... radiotherapy (5 mm enlargement). Nevus hypoautofluorescence was correlated with nevus stability ( p = 0.035). Conclusion: Retinal invasion of the choroidal nevus is rare. In this series of 8 cases, only 1 demonstrated transformation to melanoma over a mean interval of 40 months. Long-term monitoring...

...Stephanie E. Honig; Archana Srinivasan; Carol L. Shields Background: We report a case of suprachoroidal hemorrhage simulating choroidal melanoma in a patient with idiopathic thrombocytopenic purpura (ITP). Methods: Case report. Results: A 79-year-old white male with a history of lung adenocarcinoma...

...Wu Liu; Jenna May Kim; Benjamin K. Young; Ravinder Nath; Zhe Chen; Roy H. Decker; Melvin A. Astrahan; Renelle Pointdujour-Lim Background: While traditional eye plaque brachytherapy can be used for the treatment of iris melanoma, it faces challenges of poor patient tolerability due to cornea-plaque...

...Caroline Baily; Valerie O’Neill; Mary Dunne; Moya Cunningham; Giuseppe Gullo; Susan Kennedy; Paul M. Walsh; Sandra Deady; Noel Horgan Purpose: To report the clinical features and epidemiology of uveal melanoma in Ireland. Methods: This was an observational study of 253 patients with a new diagnosis...

...Meera D. Sivalingam; Lauren A. Dalvin; Carol L. Shields; Arman Mashayekhi; Jerry A. Shields To report a case of amelanotic ciliochoroidal melanoma in a patient with oculocutaneous albinism. A 76-year-old Caucasian male with a past medical history of oculocutaneous albinism and recurrent urothelial...

...Larissa Ioannidi; Konstantinos Seliniotakis; Georgios Bontzos; George Sourvinos; Viktor Haniotis; Irene Tsiapa; Thomas G. Maris; Efstathios T. Detorakis Introduction: Imaging of small peripheral choroidal melanomas remains challenging in clinical and experimental settings, requiring wide-field...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Melanoma Choroidal neoplasms Plaque brachytherapy Radiation exposure...

... alleged insufficient intervention resulting in loss of vision and/or death. The most common clinical entities were uveal melanoma (31.3%), retinoblastoma (12.5%), and sebaceous cell carcinoma (12.5%). Conclusions: Ocular oncology malpractice litigation was relatively rare and outcomes generally favored...

... and esthetic reasons. Malignant transformation of the nevus occurred in the inferior eyelid, with the appearance of a new pigmented flat lesion. Histology showed in situ melanoma, and an NRAS activating mutation was found. A full-thickness excision of the inferior eyelid was performed, followed...