... of intravitreal topotecan treatment of LCNEC metastasis to the eye. An alternative therapy that does not carry the risk of radiation optic neuropathy is intravitreal injections of chemotherapy. Intravitreal injections of anti-VEGF have been used to treat intraocular metastases with mixed success [9, 10...

...Jesse L. Berry; Sona Shah; Fiona Kim; Rima Jubran; Jonathan W. Kim Background: Intravitreal injection of melphalan (IVM) is safe and effective for the treatment of seeding in retinoblastoma. Current protocols require weekly injections during examination under anesthesia (EUA). To avoid additional...

...-arterial, or intravitreal injections. Method: A novel intracameral chemotherapy technique is described to control aqueous seeding in a pilot unilateral group E retinoblastoma case with primary aqueous seeding. Anterior segment toxicity was carefully monitored. Results: Control of the retinal tumor...

...: Pharmacokinetics of melphalan after intravitreal injection in a rabbit model. J Ocul Pharmacol Ther 2016;32:230-235. 10. Yousef YA, Soliman SE, Astudillo PP, Durairaj P, Dimaras H, et al: Intra-arterial chemotherapy for retinoblastoma: a systematic review. JAMA Ophthalmol 2016;134:584-591. 11. Munier FL...

...Niels J. Brouwer; Gregorius P.M. Luyten; Sjoerd G. van Duinen; Martine J. Jager; Marina Marinkovic Purpose: This paper reports a case of pigmented conjunctival lesions after intravitreal injections in a patient who received brachytherapy for uveal melanoma. Methods: Clinical and histopathological...