Tissue diagnosis with vitreous and/or retinal biopsy usually confirms the diagnosis of primary vitreoretinal lymphoma. Multiple imaging modalities like fundus fluorescein angiography, fundus autofluorescence, and optical coherence tomography have been used to support the diagnosis of vitreoretinal lymphoma. We report a case of a 74-year-old lady diagnosed with primary vitreoretinal lymphoma showing a novel fluorescein angiographic finding of capillary dropout. We hypothesize that this clinical finding on the fluorescein angiogram may be due to the occlusion of the retinal vasculature by the malignant tumor cells. This finding also suggests the possible intraocular invasion of the malignant lymphomatous cells into the inner retinal layers.

Keywords:
Vitreoretinal lymphoma, Capillary dropout, Fluorescein angiography
1.
Chan CC, Buggage RR, Nussenblatt RB: Intraocular lymphoma. Curr Opin Ophthalmol 2002;13:411-418.
2.
Raparia K, Chang CC, Chévez-Barrios P: Intraocular lymphoma: diagnostic approach and immunophenotypic findings in vitrectomy specimens. Arch Pathol Lab Med 2009;133:1233-1237.
3.
Levasseur SD, Wittenberg LA, White VA: Vitreoretinal lymphoma: a 20-year review of incidence, clinical and cytologic features, treatment, and outcomes. JAMA Ophthalmol 2013;131:50-55.
4.
Ishida T, Ohno-Matsui K, Kaneko Y, Tobita H, Shimada N, Takase H, Mochizuki M: Fundus autofluorescence patterns in eyes with primary intraocular lymphoma. Retina 2010;30:23-32.
5.
Casady M, Faia L, Nazemzadeh M, Nussenblatt R, Chan CC, Sen HN: Fundus autofluorescence patterns in primary intraocular lymphoma. Retina 2014;34:366-372.
6.
Fardeau C, Lee CP, Merle-Béral H, Cassoux N, Bodaghi B, Davi F, Lehoang P: Retinal fluorescein, indocyanine green angiography, and optic coherence tomography in non-Hodgkin primary intraocular lymphoma. Am J Ophthalmol 2009;147:886-894, 894.e1.
7.
Velez G, Chan CC, Csaky KG: Fluorescein angiographic findings in primary intraocular lymphoma. Retina 2002;22:37-43.
8.
Mapelli C, Invernizzi A, Barteselli G, Pellegrini M, Tabacchi E, Staurenghi G, Viola F: Multimodal imaging of vitreoretinal lymphoma. Ophthalmologica 2016;236:166-174.
© 2017 S. Karger AG, Basel
2017
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.