.... Alterations in topoisomerase II activity may also be involved in drug resistance. More recently, expression of the HER-2/neu oncogene or mutations of the p53 tumor suppressor gene were found to be associated with drug resistance, and gene therapy trials with transfer of wild-type p53 into lung cancer cells...

... oncogenes: c-fos, c-jun, H-ras, and p53. Based on these findings, strategies are discussed for the use of ribozymes, catalytic RNAs, to suppress gene expression and reverse the observed drug resistance. 12 5 2009 © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright...

... the concerted action of p53 and the retinoblastoma protein may induce either a cell cycle arrest or apoptosis in response to genomic damage. Several other checkpoint functions regulate the entry into mitosis by assessing the completion of DNA replication and correct chromosome attachment to the spindle...

...F. Porzsolt; M. Schmid; D. Höher; R. Muche; W. Gaus; M. Montenarh Increasing evidence supports the function of p53 as suppressor gene. Auto-antibodies against the product of this gene are frequently found in cancer patients. There is little information on the stages of the diseases where...