... triplet chemotherapy regimens in this setting. We report the treatment outcome in 3 patients with HER2-positive metastatic gastric cancer who were treated with trastuzumab plus the triplet FLOT regimen (5-fluorouracil/leucovorin, oxaliplatin, and docetaxel). Patients and Methods: 3 patients with HER2...

...Yi Chen; Xiaolin Wang; Zhiping Yan; Jianhua Wang; Jianjun Luo; Qingxin Liu Background: The aim of this study was to evaluate the therapeutic efficacy and safety of hepatic arterial infusion (HAI) with irinotecan, oxaliplatin, and floxuridine as a firstline treatment in patients with unresectable...

...Andrew K. Chan; Bok A. Choo; John Glaholm Background: Oxaliplatin in combination with either 5-fluorouracil or capecitabine is commonly used in the treatment of colorectal cancer and is rarely associated with pulmonary toxicity. This is the first reported case of oxaliplatin and capecitabine/5...

...Roger von Moos; Arnaud Roth; Thomas Ruhstaller; Lucas Widmer; Catrina Uhlmann; Richard Cathomas; Dieter Köberle; Mathew Simcock; Doris Lanz; Razvan Popescu Background: A phase I multicentre trial was conducted to define the recommended dose of capecitabine in combination with oxaliplatin...

... widersprÜchlicher Daten derzeit kontrovers diskutiert. Die Frage, ob vor der Therapieentscheidung bei Stadium-II-Patienten der MSI-Status ÜberprÜft werden soll, kann deshalb zurzeit nicht einheitlich beantwortet werden. FÜr die adjuvante Therapie im Stadium III steht mit Capecitabin/Oxaliplatin (XELOX) jetzt ein...

...Werner Scheithauer; Wolff Schmiegel The anti-angiogenic, monoclonal antibody bevacizumab, in combination with chemotherapy, is proven to prolong survival in metastatic colorectal cancer. Recent data demonstrate that combining bevacizumab with widely used oxaliplatin-containing chemotherapy regimens...

...Raffaele Nardone; Thomas Buratti; Stefan Golaszewski; Arianna Bratti; Francesca Caleri; Frediano Tezzon; Gunther Ladurner; Manfred Mitterer Background: To date, only a few cases have been reported that indicate that a delayed polyneuropathy may occur after chemotherapy with oxaliplatin...

..., for most of these patients treatment options are limited, and no standard first-line regimen has been identified. We performed a phase II study with oxaliplatin (OX) and capecitabine (CAP) as first-line treatment for patients with histo-or cytologically proven adeno- or undifferentiated CUP. Patients...

...Uwe Pelzer; Jens Stieler; Lars Roll; Andreas Hilbig; Bernd Dörken; Hanno Riess; Helmut Oettle Background: This phase II trial investigated the efficacy and safety of oxaliplatin (O), 5-fluorouracil (5-FU), and folinic acid (FA) (OFF) as second-line treatment for patients with metastatic pancreatic...

...%), 7 stable disease (44%). Median time to progression was 219 days (range 50–387 days). Conclusion: Gefitinib at a dose of 250 mg daily in combination with weekly 5-fluorouracil at 2,000 mg/m 2 or gefitinib at a dose of 500 mg daily with 5-fluorouracil at 1,600 mg/m 2 plus oxaliplatin has an acceptable...