.... The expression of the MDR1 gene occurs to various degrees. The multidrug resistance-associated protein is also present in lung cancer cells. Enhanced activities of gluta-thione S-transferases and elevated glutathione levels of tumor cells may contribute to the intrinsic resistance of non-small-cell lung cancer...

... trigger cellular transformation. In this study, the role of oncogenes was defined in drug-resistant human ovarian carcinoma cells. In both multidrug resistant (actinomycin D) cells and non-multidrug-resistant (cisplatin) cells, Northern analyses demonstrated enhanced gene expression for the following...

... for in vivo reversal of multidrug resistance. 11 5 2009 © 1995 S. Karger AG, Basel 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic...

...M. Raderer; D. Depisch; K. Haider; W. Kwasny; M. Djavanmard; W. Scheithauer Background : Because MDRl RNA is frequently encountered in advanced breast cancer, we have initiated a phase I/II study with pirarubicin in combination with the multidrug resistance modifier quinidine. Patients and Methods...