... or in combinations. We studied the case of a 58-year-old female who developed liver lung metastases 4 years after nephrectomy had been performed due to RCC. Methods : We administered an alternating combination of recombinant interferon-alpha (IFN-alpha)/interleukin-2 (IL-2) respectively interferon-gamma (IFN-gamma...

...I. Funke; E. Späth-Schwalbe; G. Stohlmann; O. Prümmer; H. Gallati; H. Schrezenmeier; F. Porzsolt Background: In advanced renal cell cancer (RCC) interleukin-2 (IL-2) and interferon-α (IFN-α) have shown modest clinical activity as single agents, substantial toxicity being associated with IL-2...

...R. Morant; J. Richner; M. Aapro; P.A. Palmer; H.J. Senn Background: On the basis of encouraging preclinical data, we investigated the combination of the 2 agents recombinant interferon-alpha 2b (IFN-alpha) and recombinant interleukin-2 (rIL-2) in the treatment of patients with metastatic renal cell...

...L. Bergmann; E. Weidmann; P.S. Mitrou; U. Runne; U. Keilholz; H.H. Bartsch; C.R. Franks In vitro, the combination of interleukin-2 (11–2) with interferon-α (IFN-α) seems to act synergistically on the generation of lymphokine activated killer (LAK) cells. Due to this fact two clinical trials...

...L. Bergmann The induction and activation of autologous cytotoxic cells (lym-phokine activated killer cells = LAK) by interleukin-2 (Il –2) is an interesting new approach in cancer treatment. So far, Il –2 alone or in combination with the transfer of in vitro activated LAK (adoptive immunotherapy...

...S. Burdach; L. Levitt; V. Wahn; U. Göbel Die Aktivierung der Gene für Interleukin-2 (IL2) und seinen Rezeptor durch das tat-Genprodukt des menschlichen Retrovirus HTLV-I ist mit der Pathogenese der adulten T-Zell-Leukämie assoziiert worden. In vorangegangenen Untersuchungen haben wir gezeigt, daß...