...Uğur Coşkun; Ali Osman Kaya; Necati Alkıs; Süleyman Buyukberber; Süleyman Alıcı; Gökhan Celenkoglu; Doğan Uncu; Metin Özkan; Alper Sevinc; Mustafa Benekli Background: We retrospectively evaluated the activity and toxicity of uracil/tegafur (UFT) plus oral folinic acid in combination...

... and III patients. However, modulation and schedule of application as well as optimal duration of 5-FU therapy are still subject of discussion. Experimental and clinical data show a potentiation of 5-FU cytotoxicity by folinic acid (FA), and the combination of 5-FU and FA might become standard...

...M. Lorenz; E. Staib-Sebler; C. Gog; H. Petrowsky; A. Encke Background: Effective second-line treatments of inoperable metastatic colorectal cancer are rare. Therefore, the efficacy and toxicity of weekly intravenous high-dose infusions of 5-fluoro-uracil (5-FU) and folinic acid (FA) in pretreated...

... treatment with 5-fluorouracil (5-FU) and levamisole (LEV) is recommended as standard treatment for Dukes C colon cancer; for rectal cancer (Dukes B2-C) radiation and 5-FU single-agent chemotherapy is considered treatment of choice. Progress for therapy is expected by the introduction of folinic acid (FA...

...C. Stoffregen; K.-H. Zurborn; V. Boehme; A. Schmid; G. Lorenz; T. Arendt; U.R. Fölsch Background: Weekly high-dose 5-fluorouracil (5-FU; 24-hour infusion of 2.6 g/m 2 ) and folinic acid (FA; 500 mg/m2as 1- or 2-hour infusion) proved to be effective in patients with metastatic colorectal cancer...

... cisplatin (P) to the combination of folinic acid, etoposide, and 5-FU (ELF), which is one of the newer and active regimens for the treatment of advanced gastric cancer. Patients and Methods : 29 patients with advanced gastric cancer were treated with folinic acid (300 mg/m2), etoposide (100 mg/m2), 5-FU...

...N. Tsavaris; N. Mylonakis; Ch. Bacoyiannis; G. Papastratis; M. Katsikas; V. Papadimitrakopoulou; A. Macheras; A. Stamelou; P. Kosmidis Background : The combination of 5-fluorouracil (5-FU) and folinic acid (FA) has demonstrated activity in most gastrointestinal tumors. The addition of epirubicin...

.... Colorectal carcinoma, metastatic 5-Fluorouracil Interferon Folinic acid Biochemical modulation LAUFENDE KLINISCHE STUDIE ONGOING CLINICAL TRIAL Onkologie 1995;18:131-135 R. Moser" Hansmaningerb Ludwigc M. Fridrikd H. Schmidt1' B. Mlineritschb M. Pecherstorferc G. MichlmayrCh. K opf8 II. Samonigg8 5...

... found. Following a postoperative chemotherapy with 5-fluorouracil (5-FU) and folinic acid (FA) (3 cycles) a significant regression of the metastases became evident. In absence of further distant metastases and local recurrence the potentially curative resection of the hepatic metastases was performed...

..., though this is not a proven method to date. Aim: As an alternative to the FUDR fluorodesoxyuridine) therapy with its high local toxicity, we assessed a regional therapy with 5-FU (fluorouracil) using the modulation with FA (folinic acid) as a continuous application. Patients and Methods: In 16 patients...

.... Thiel Background : The biochemical rationale for the use of folinic acid (FA) and interferon (IFN) to modulate and thereby enhance the antitumor activity of 5-fluorouracil (5-FU) in vitro has been well established. Based on randomized trials comparing 5-FU alone and 5-FU and FA, the combination has been...

...B. Steinke; E. Günther; W. Hirschmann; W. Sondern; K.H. Koniczeck; H.E. Wander; F. Natt; T. Wagner; H.F. Hinrichs; W. Roth Background: In most studies comparing 5-fluorouracil (5-FU) monotherapy versus the combination of folinic acid and 5-FU in the treatment of advanced colorectal cancer, a low...

... patients. Efficacy of treatment or prophylaxis with nitrates or calcium channel blockers was unpredictable. The addition of folinic acid to 5-FU in an own cohort of 339 patients with gastrointestinal cancers does not add to the cardiotoxic potential nor does it change the spectrum of signs and symptoms...

... and overall survival. Recent data and analyses indicate that the combination of 5-fluorouracil and folinic acid, which shows high efficacy in advanced stages of colorectal carcinoma, is effective in the adjuvant setting too. During 1992/1993 in Germany five multicenter, prospective randomized trials were...

...M.E. Heim; D. Schuster; H. Flechtner; P. Worst; W. Queiβer 27 patients with advanced colorectal cancer were treated in a phase-II trial with high dose sequential methotrexate (MTX), 5-fluorouracil (5-FU), and folinic acid (FA). Following a 4h infusion of 800mg/m 2 MTX and a 4h interval, 1,500 mg/m...