... cisplatin-based chemotherapy. Patients and Methods: A retrospective analysis of the incidence of and risk factors for VTEEs in 193 GCT patients receiving platinum-based chemotherapy in Hamburg, Germany, between 2000 and 2009 was performed. Results: VTEEs occurred in 22 patients (11%). In only 4 patients...

...Tomasz Jurek; Marta Rorat; Piotr Dys; Barbara Swiatek Background: Cisplatin is a chemotherapeutic agent that may cause acute (or chronic) organ toxicity. As there is no antidote, prevention of adverse drug events is essential for patients’ safety. Case Report: The authors present the case of a 33...

...Kayvan Khadjooi; Naghme Adab; Anthony Kenton Background: Cisplatin-based chemotherapy – mainly the bleomycin, etoposide and cisplatin (BEP) regimen – has significantly improved the prognosis of testicular germ cell tumours (GCT). However, it has serious vascular side effects, including acute...

... both response to and survival after docetaxel and cisplatin combination chemotherapy in inoperable or recurrent head and neck squamous cell carcinoma. Patients and Methods: A total of 54 patients were treated with frontline systemic chemotherapy composed of docetaxel (60 mg/m 2 ) and cisplatin (65 mg/m...

...Efraim Idelevich; Hanoch Kashtan; Yoram Klein; Victor Buevich; Noa Ben Baruch; Michael Dinerman; Margarita Tokar; Yulia Kundel; Baruch Brenner Background: We investigated the efficacy and tolerability of cisplatin and 5-fluorouracil (5-FU) plus bevacizumab as neoadjuvant therapy for patients...

...Silvia Park; Soohyeon Lee; Jeeyun Lee; Se Hoon Park; Joon Oh Park; Won Ki Kang; Young Suk Park; Ho Yeong Lim Background: In relapsed germ cell tumors, salvage chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP) is a well-established regimen for patients with favorable features...

...Claus Rödel Standardtherapie des Analkanalkarzinoms ist die definitive Radiochemotherapie (RCT) mit 5-Fluorouracil plus Mitomycin C. Eine Induktionschemotherapie, Erhaltungschemotherapie oder der Ersatz von Mitomycin C durch Cisplatin erwiesen sich in Phase-III-Studien als nicht sinnvoll. Neuere...

...Zheng-Fei Zhu; Min Fan; Xiao-Long Fu Background: Radiation recall dermatitis (RRD) is an inflammatory skin reaction in a previously irradiated field in response to certain pharmacological agents. Little is known about the potential risk of RRD in response to the use of vinorelbine and cisplatin...

...Thorleif Etgen; Georg Weidenhöfer; Thomas Kubin Background: Cisplatin is a highly effective antineoplastic agent used also in germ cell cancer. Thromboembolic complications like pulmonary embolism, myocardial infarction and stroke have occasionally been reported. Case Report: A 46-year-old man...

... with cisplatin single-agent chemotherapy. Results: Tolerance of therapy was acceptable with 1 grade I and 1 grade II renal toxicity. 6 patients experienced grade III haematological toxicity. Partial remission of the disease was observed in 6 cases, and 6 patients could receive combination chemotherapy after...

... application of cisplatin and inhalation anaesthetics, was investigated. The genotoxicity of anaesthetics on Ehrlich ascites tumour (EAT) cells of mice, alone or in combined application with cisplatin, was estimated by using the alkaline comet assay. The percentage of EAT cell apoptosis was quantified by flow...

... trigger cellular transformation. In this study, the role of oncogenes was defined in drug-resistant human ovarian carcinoma cells. In both multidrug resistant (actinomycin D) cells and non-multidrug-resistant (cisplatin) cells, Northern analyses demonstrated enhanced gene expression for the following...

...H. Wilke; P. Preusser; M. Stahl; H.J. Meyer; U. Fink; W. Achterrath; P. Busche; J. Meyer; A. Harstrick; H.-J. Schmoll; S. Seeber Background : Cisplatin is an active drug in advanced gastric cancer and acts synergis-tically with etoposide and 5-fluorouracil (5-FU). These were the reasons for adding...

... alterations in big vessels and capillaries of rats after application of cisplatin were studied. Materials and Methods: 60 female WAG/Rij rats were treated with a total dose of 12.6 mg/kg body weight cisplatin injected into the left jugular vein in 9 equal fractions over 3 weeks. Vascular damages of the common...

...A. du Bois; H.G. Meerpohl; C. Wilhelm; L. Quaas; I. Barnickel; A. Pfleiderer Emesis unter Cisplatin (DPP)-haltiger Chemotherapie ist ein noch ungelöstes Problem und führt in bis zu 10% der Fälle zum Abbruch einer potentiell kurativen Therapie. Wir untersuchten die antiemetische Wirksamkeit des...

...H. Henß; H.H. Fiebig; J. Schildge; H. Arnold; J. Hasse Die Kombination von Doxorubicin und Cisplatin wurde in einer Phase-II-Studie bei Patienten mit fortgeschrittenen malignen Pleuramesotheliomen untersucht. 19 Patienten erhielten intravenös Cisplatin 60 mg/m 2 /Tag, Tag 1 und 2, und Doxorubicin...

...P. Drings; H. Becker; H. Bülzebruck; N. Djawid; E. Ruchalla; P. Stiefel; H.W. Tessen 192 unbehandelte Patienten mit histologisch gesichertem nicht-klein-zelligem Bronchialkarzinom wurden im Rahmen von 3 Phase-II-Studien mit den Kombinationen Ifosfamid 2g/m 2 an den Tagen 1–5 und Cisplatin 75 mg/m 2...

...H. Sauer; W. Mair; U. Fink; H. Rückle; I. Mjaaland; W. Wilmanns 34 Patienten mit lokal fortgeschrittenem und/oder metastasiertem Weichteilsarkom wurden mit 4’-Epi-Adriamycin (4’-Epi-DX: 45 mg/m 2 Tag 1+2) und Cisplatin (DDP: 90mg/m 2 Tag 2) behandelt. Pro Therapiezyklus wurde die 4’-Epi-DX-Dosis um...

...G. Koschel; E. Kaukel; E. Hain 45 Patienten (39 Manner, 6 Frauen) mit inoperablem nicht-kleinzelligem Bronchialkarzinom wurden mit einer Kombination aus Mitomycin C, Vindesin und Cisplatin behandelt. Alle Patienten waren unbehandelt und hatten meßbare Tumorparameter. Der Karnofsky-Index lag bei...

...U. Gatzemeier; R. Zschaber; D.K. Hossfeld; D. Radenbach In einer Phase-II-Studie, in die von Juli 1981 bis November 1982 60 unbehandelte Patienten mit inoperablem. nicht-kleinzelligen Bronchialkarzinom auswertbar aufgenommen wurden, wurde die Wirkung einer Kombination aus Cisplatin, Vindesin und VP...