... pain, with a stepped approach being generally recommended. In the past decade, the bisphosphonates, which reduce bone turnover, increase bone mass, and decrease the risk of fracture, have become established as an effective treatment in patients with cancer metastasising to bone. The nitrogencontaining...

... local recurrence. Case Report: We report on a 33-yearold male patient with sacral giant cell tumor treated with intravenous bisphosphonate therapy after early failure of embolization procedures. At 3 years follow-up, the patient had no pain, no neurological deficits, and no local recurrence. Conclusion...

... and Palliative Care Unit, First Department of Radiology, Areteion Hospital, University of Athens, School of Medicine, bSecond Department of Radiology, Attikon University Hospital, Athens University Medical School, Athens, Greece Keywords Liposarcomas · Bone metastases · Local recurrence · Bisphosphonates...

...George Bozas; Anu Roy; Vani Ramasamy; Anthony Maraveyas Background: Osteonecrosis of the jaw (ONJ) is recognised as an important adverse effect of intravenous bisphosphonates. Recent reports have suggested that antiangiogenic agents may promote the development of this condition. Case Report: We...

... bisphosphonate, which is an elementary part of the standard therapeutic regimen of MM. Patients and Methods: We evaluated the tolerability of ibandronate 2–6 mg every 4 weeks in patients with MM and ESRD receiving regular hemodialysis over 12 weeks (open-label, single-center, observational study). Ibandronate...

...F. Bauss Ibandronate is an aminobisphosphonate that targets bone and inhibits osteoclasts. It is one of the most potent bisphosphonates currently under clinical investigation in metabolic bone disease and osteoporosis. In animal models ibandronate is 2, 10, 50 and 500 times more potent than...

...M.E. Heim; M.R. Clemens; W. Queißer; M. Pecherstorfer; Ch. Boewer; M. Herold; A. Franke; Z. Herrmann; R. Loose; L. Edler Background : Characteristic features of multiple myeloma are bone resorption, osteoporosis and osteolytic lesions. Bisphosphonates can inhibit osteoclast activity and bone...

...B. Müsel; P. Scigalla The bisphosphonates are substances which are chemically characterized by a P-C-P bond. As analogues of pyrophosphate these compounds have a high affinity for bone mineral and only little or no effect on other tissues. Acute and chronic toxicity studies revealed the kidney...

... information to conventional histological measurement by clarifying the extent and location of metastatic infiltration and the tumor growth pattern. The score can also be used to assess the action of bisphosphonates on bone metastases. Materials and Methods: Male nude rats (n = 12 per group) were inoculated...