34 Patienten mit lokal fortgeschrittenem und/oder metastasiertem Weichteilsarkom wurden mit 4’-Epi-Adriamycin (4’-Epi-DX: 45 mg/m2 Tag 1+2) und Cisplatin (DDP: 90mg/m2 Tag 2) behandelt. Pro Therapiezyklus wurde die 4’-Epi-DX-Dosis um 5 mg/m2 pro Therapietag gesteigert, falls zum Zeitpunkt des Leukozyten- bzw. Thrombozy-ten-Nadirs im vorhergehenden Intervall die Werte 2000/mm3 bzw. 70000/mm3 nicht unterschritten. Ein Patient schied durch tumorbedingten Tod nach dem ersten Therapiezyklus aus. Bei den restlichen, für den Therapieeffekt auswertbaren Patienten wurden 4 (12%) Vollremissionen, 10 (30%) Teilremissionen und 15 (46%) Stabilisierungen beobachtet. Bei 4 Patienten (12%) war das Tumorwachstum unter der Therapie primär progredient. Bei 6 Patienten wurde die Therapie vorzeitig abgebrochen: 4mal Therapieresistentes Erbrechen, lmal Ototoxizität, lmal vermutete Kardiotoxizität. Die Hämatotoxizität war kein limitierender Faktor für diese Therapie.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.