Durch die Kombination serologischer Marker synchron mit dem Ein-satz radiologischer und morphologischer Methoden läßt sich die dia-gnostische und prognostische Aussage beim Ovarialkarzinom wesentlich verbessern. In einer prospektiven Studie zwischen 1977 und 1983 wurde die Validität folgender Marker geprüft: Sialyltransferase, CEA, TPA, SP-1, SP-3, Alpha-1-Antitrypsin, Alpha-2-Makroglobulin, C-reaktives Protein. Die Ergebnisse wurden mit denen der CA-12-5-Bestimmung korreliert. Präoperativ angezeigt wurden Ovarialkarzinome durch CA 12-5 (93,7%), Sialyltransferase (65,6%), TPA (53,1%), CEA (28,1%). Diese Marker dürften auch zur Kontrolle des klinischen Verlaufs geeignet sein.

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