Aclacinomycin A (ACM) wurde zur Behandlung rezidivierter oder primär chemotherapieresistenter akuter Leukämien eingesetzt. Die Dosierung betmg 25 mg/m2 i.v. täglich an 7 aufeinanderfolgenden Tagen. Von den 21 behandelten Patienten sind 17 auswertbar, 2 mit akuter lymphatischer und 15 mit akuter myeloischer Leukämie. Bei den akuten myeloischen Leukämien sind 2 komplette und eine partielle Remission erzielt worden. Die partielle Rückbildung der leukämischen Knochenmarkinfiltration ist bei einer Kranken mit primärer Resistenz gegen Daunorubicin und Adriamycin beobachtet worden. Bei den Patienten mit akuter lymphatischer Leukämie wurde keine Remission erzielt.

Keywords:
Aclacinomycin A, Akute myeloische Leukämie, Akute lymphatische Leukämie
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© 1983 S. Karger AG, Basel
1983
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