In der Gewebekultur werden Fibroblasten, Endothelzellen und glatte Muskelzellen aus Arterienwand von Thrombin und Faktor XIII in ihrem Wachstum stimuliert, während Fibronectin die Proliferation dieser Zellen hemmt. Vergleichende Untersuchungen mit Tumorzellen zeigen eine stimulierende Wirkung von Thrombin und Faktor XIII auf Sarkomzellen und HeLa-Zellen. Fibronectin hemmt das Wachstum von Sarkomzellen. Die Proliferation von HeLa-Zellen wird dagegen von Fibronectin in physiologischen Konzentrationen deutlich stimuliert. Es werden mögliche Wirkmechanismen der Wachstumsfaktoren diskutiert und Bezüge zu in vivo-Phänomenen hergestellt.

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