In einer retrospektiven Betrachtung wurden 72 Patientinnen mit disse-miniertem Mammakarzinom unter einer zytostatischen Dauertherapie mit Cyclophosphamid und Methotrexat untersucht. Die Dauertherapie wurde nach Ausschöpfung der lokaltherapeutischen und hormonellen Therapiemaβnahmen sowie nach durchschnittlich vier aggressiven Chemotherapiezyklen nach Salmon und Jones eingeleitet. Die mittlere Überlebenszeit nach Einleitung der Polychemotherapie betrug 19 Monate. Es konnte gezeigt werden, daβ die milde Erhal-tungstherapie nach Remissionseinleitung mit einem aggressiven The-rapieschema keine Nachteile im Vergleich zu einer konsequent durch-geführten Induktionstherapie erwarten läβt, jedoch eine erhebliche Verbesserung der Lebensqualität bringen kann.

Keywords:
Mammakarzinom, Chemotherapie, Erhaltungstherapie
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© 1982 S. Karger AG, Basel
1982
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