Bei 84 Mammakarzinompatientinnen wurde präoperativ die zelluläre Immunität untersucht. 47 Patientinnen waren frei von regionären und Fernmetastasen, 37 Patientinnen hatten bereits axilläre Lymphkno-ten- aber noch keine Fernmetastasen. Als Kontrollkollektiv dienten 32 klinisch gesunde Frauen. In bezug auf die Leukozytenzahl und den prozentualen T-Zell-Anteil an der Gesamtlymphozytenpopulation ergaben sich zwischen gesunden Frauen und den Mammakarzinompatientinnen keine Unterschiede. Die Karzinompatientinnen wiesen jedoch gegenüber dem Kontrollkollektiv eine signifikant erhöhte Lymphozytenzahl auf. Trotz quantitativer Zunahme der Lymphozyten konnte bei den Mammakarzinompatientinnen eine signifikant ernied-rigte Concanavalin-A-Stimulationsfähigkeit nachgewiesen werden. Bei den Mammakarzinompatientinnen mit regionären Lymphknoten-metastasen war auch die Stimulationsfähigkeit durch Phytohämagglutinin erniedrigt.

Keywords:
Zelluläre Immunität, Phytohämagglutinin, Concanavalin-A-Stimulation, T-Lymphozyten
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© 1982 S. Karger AG, Basel
1982
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