Bei einem Säugling und einem Kleinkind mit metastasiertem Neuroblastom konnten Chromosomen direkt aus Primärtumor und Knochenmarkmetastasen präpariert werden. Insgesamt 765 Tumormetaphasen konnten nach Giemsa-Bandenfärbung gezählt und teilweise karyotypisiert werden. »Double Minute« Chromosomen wurden in den Metaphasen sowohl des Primärtumors und der Metastasen bei dem Säugling gefunden, aber nur im Primärtumor des anderen Kindes. Strukturell auffällig neben anderen Translokationen war in beiden Fallen der kurze Arm von Chromosom Nr. 1. Die modale Chromosomenzahl betrug bei dem Säugling 46 im Primärtumor und Knochenmark, bei dem Kleinkind 84 im Primärtumor und 46 und über 100 im Knochenmark. Eine klonale Evolution der Neuroblastomzellen bei Metastasierung wird diskutiert.

Keywords:
Metastasiertes Neuroblastom, Chromosomenanalyse
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© 1982 S. Karger AG, Basel
1982
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