Die Zwischenauswertung einer kontrollierten Studie zur Behandlung von 33 Patienten mit Plattenepithelkarzinomen des Kopf-Hals-Berei-ches mit Therapiearm A: cis-DDP (3 mg/m2 Tag 1) plus Bleomycin (15 mg i.v. kontinuierlich Tag 2–6) gegen Therapiearm B: Methotrexat (30 mg/m2 i.v. Tag 1 und 6) plus Vindesin (3 mg/m2 i.v. Tag 2 und 7) zeigte folgende Ergebnisse: komplette Remission (KR): l× A, O× B; partielle Remission (PR): 6× A, 4× B; Ansprechen (AN): 3× A, 7× B; unveränderter Verlauf (UV): 2× A, O× B; Progression (PG): 5× A, 5× B. 8 Patienten wurden wegen Progression auf den alternativen Arm mit folgenden Ergebnissen überführt. KR: l× A; AN: l× A, 2× B; UV: l× B; PG: 3× A. Bei Zuteilung dieser Resultate zu prognostischen Faktoren geht hervor, daß nicht vorbehandelte (NV) Patienten eindeutig von einer primären Therapie profitieren gegenüber vorbehandelten (V): KR + PR:8× NV(=53%),4× V(6=22%);UV + PG:1×NV(= 7%), 7× V(= 39%).

Keywords:
Plattenepithelkarzinom, Kopf-Hals-Bereich, cis-Platinum, Bleomycin, Methotrexat, Vindesin
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© 1981 S. Karger AG, Basel
1981
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