Hypophysenmetastasen sind selten. Angaben über die Inzidenz in Autopsieserien schwanken zwischen 1,8 und 12% der metastasieren-den Tumoren. Die meisten finden sich beim Mammakarzinom, gefolgt von Karzinomen des Magen-Darm-Traktes. Klinisch werden nur 20% manifest in Form eines Diabetes insipidus – entsprechend dem bevorzugten Befall des Hypophysenhinterlappens. Es werden die Besonderheiten eines Falles von Prostatakarzinom mit Hypophysenmetastase diskutiert, bei dem eine Funktionsstörung der parasellär verlaufenden Hirnnerven zur Diagnose führte. Die Behandlung mit Flutamid erbrachte eine Remission. Die Überlebenszeit war mit 18 Monaten lang.

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