Nach heutiger Vorstellung werden Zellreifung und -proliferation in der Hamatopoese wesentlich vom Gewebsmikroenvironment sowie von spezifischen löslichen inhibierenden oder stimulierenden Mediatoren beeinflußt. Dem HLA-System scheinen dabei wichtige Funk-tionen in der Regulation der physiologischen und pathologischen Hamatopoese zuzukommen. Insbesondere soil die Qualítät und Quantität der Expression von HLA-Antigenen für Interaktionen vor allem von supprimierenden Faktoren mit hämatopoetischen Vorläu-ferzellen von Bedeutung sein. Ferner können HLA-Antigene Einflüsse von T-Lymphozyten auf die Produktion von Kolonie-stimulierenden oder -inhibierenden Faktoren sowie auf die Proliferation hämatopoetischer Zellen vermitteln. Das HLA-System könnte daher mit wichtigen Regulatorfunktionen des Immunsystems in der Hamatopoese in Zusammenhang stehen.

Keywords:
HLA-Antigene, Hamatopoese, Immunregulation der Hämatopoese
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© 1987 S. Karger AG, Basel
1987
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