... were performed. Results: Omentin did not affect skeletal muscle insulin signaling, as assessed by basal and insulin-stimulated phosphorylation of IRS1 and AKT. Omentin increased basal, but not insulin-stimulated glucose uptake. While increased glycolytic activity was confirmed by elevated lactate...

...Xing Ge; Qingqing Wang; Tingting Yao; Jiafei Xie; Chaoran Zhang; Li-Chun Xu Introduction: This study aimed to understand the transcriptome characteristics of the skeletal muscle of elderly (EL) men with metabolic syndrome (MS) and to find the hub genes and insight into the molecular mechanisms...

... both the maintenance of skeletal muscle and the reduction of adipose tissue after LSG. The identification of the relationship between preoperative serum IGF-1 and body composition changes after LSG can help in understanding the pathophysiology of obesity. Methods: We retrospectively reviewed 72...

... in a low-altitude region, HFD significantly impaired mitochondrial respiratory function and mitochondrial DNA content in skeletal muscles, which was partially reversed in mice in the HA/HFD group. In addition, the fatty acid oxidation-related enzyme gene CPT1 (carnitine palmitoyltransferase 1) and genes...

... group, the frequencies of mood disorders and binge eating were high, and a decrease in skeletal muscle mass due to low protein intake was observed. Furthermore, weight regain was shown 12 months after LSG in both groups. In the average group, there were fewer problems in weight loss outcomes, mental...

...Dorien Reijnders; Gijs H. Goossens; Gerben D.A. Hermes; Hauke Smidt; Erwin G. Zoetendal; Ellen E. Blaak Objective: To investigate the impact of gut microbiota manipulation on fasting and postprandial skeletal muscle metabolism in humans. Methods: 40 obese, insulin-resistant males were randomized...

... and quality have a strong negative prognostic impact in obese individuals and may lead to frailty, disability, and increased morbidity and mortality. Awareness of the importance of skeletal muscle maintenance in obesity is however low among clinicians and scientists. The term ‘sarcopenic obesity' has been...

...%) but not in the D/Ex group (-1.4 ± 5.0%). Conclusion: Aerobic exercise attenuated the loss of skeletal muscle during energy restriction in adults with visceral adiposity. 23 04 2013 4 09 2013 23 1 2014 © 2014 S. Karger GmbH, Freiburg 2014 Open Access License / Drug Dosage / Disclaimer Open...

... insulin secretion and insulin sensitivity. In this review, an overview of the mechanisms that may underlie the association between the RAS and type 2 diabetes will be provided, with focus on skeletal muscle and adipose tissue function. This will include discussion of several human studies performed in our...

... tomography (CT) scans were obtained from 63 men and 110 women from the Quebec Family Study. Areas and attenuations of adipose tissue compartments and skeletal muscle measured from CT scans were related to glycemia and insulinemia values from an oral glucose tolerance test (OGTT). Results: Adjusted for age...