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First page of Relationship of fat deposition in the liver and pancreas with cholecystectomy

Objective: To investigate the relationship of cholecystectomy with both hepatic and intra-pancreatic fat. Methods: The study involved 367 participants who underwent abdominal scanning, with hepatic and intra-pancreatic fat quantified using gold-standard MRI-based methods. Linear regression analyses were adjusted for age, sex, ethnicity, BMI, fasting plasma glucose, fasting insulin, triglyceride, LDL-C, and HDL-C. Results: In the most adjusted model, cholecystectomy was significantly negatively associated with hepatic fat (β coefficient = -3.671; p = 0.019), but not intra-pancreatic fat (β coefficient = 0.133; p = 0.586). In analyses stratified by BMI, this association with hepatic fat was significant in the obese group only (β coefficient = -7.163; p = 0.048). The association with intra-pancreatic fat was not influenced by BMI. Conclusions: Cholecystectomy is significantly associated with lower hepatic fat in obese individuals. This affirms that people with indications for cholecystectomy should not be dissuaded from undergoing the procedure based on fears of harmful effects of increasing hepatic fat content.

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2025
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