Fig. 1. Differential expression of ESCO2 in normal and tumor tissues. a Differential expression of ESCO2 based on TCGA cohort. b Differential expression of ESCO2 based on the combination between TCGA and GTEx cohort. * p < 0.05, ** p < 0.01, *** p < 0.001. NS, not statistically ... More about this image found in Differential expression of ESCO2 in normal and tumor tissues. a Different...

Fig. 2. Association between ESCO2 expression and tumor stage. a ACC-tumor. b BRCA-tumor. c KIRC-tumor. d KIRP-tumor. e LIHC-tumor. f LUAD-tumor. g LUSC-tumor. h PAAD-tumor. i PRAD-tumor. j STAD-tumor. k BRCA-node. l COAD-node. m LUAD-node. n LUSC-node. o KIRP-node.... More about this image found in Association between ESCO2 expression and tumor stage. a ACC-tumor. b BR...

Fig. 3. Prognostic analysis of ESCO2 in pan-cancer and Kaplan-Meier survival of BLCA. a OS. b DSS. c DFI. d PFI. e OS in BLCA. f DSS in BLCA. g DFI in BLCA. h PFI in BLCA. More about this image found in Prognostic analysis of ESCO2 in pan-cancer and Kaplan-Meier survival of BLC...

Fig. 4. Immune cell infiltration analysis. The correlations of ESCO2 expression and the infiltration levels of B cells, HSC, NKT cells, macrophages, mast cells, monocytes, MDSC, neutrophils, NK cells, T-cell follicular helper, γ/δ T cells, CAF, Tregs, CD4+ T cells, CD8+ T cells, dendritic cells... More about this image found in Immune cell infiltration analysis. The correlations of ESCO2 expression and...

Fig. 5. Correlations between ESCO2 and immune molecules, TMB and MSI. a Immunoinhibitor. b Immunostimulator. c MHC molecule. d Chemokine. e Chemokine receptor. f The correlation plot of ESCO2 and CD274 in BLCA cohort. g The lollipop plot of ESCO2 and TMB in pan-cancer. h The lol... More about this image found in Correlations between ESCO2 and immune molecules, TMB and MSI. a Immunoinh...

Fig. 6. Immunotherapy in BLCA. a The fraction of BLCA patients with response to anti-PD-1 therapy in low- and high-ESCO2 subgroups. b The correlation plot of ESCO2 and TMB in BLCA immunotherapy cohort. c Kaplan-Meier curves for low- and high-ESCO2 patient groups in BLCA immunotherapy coho... More about this image found in Immunotherapy in BLCA. a The fraction of BLCA patients with response to a...

Fig. 7. KEGG and GO enrichment analysis. a–d The bubble plot of GO and KEGG enrichment analysis in upregulated DEGs. e–h The bubble plot of GO and KEGG enrichment analysis in downregulated DEGs. More about this image found in KEGG and GO enrichment analysis. a–d The bubble plot of GO and KEGG enric...

Fig. 8. Clinical Case. a Time axis of the patient’s visit experience and enhanced CT images. b Immunohistochemical staining pictures of ESCO2, CD3, CD4, CD8, CD274 in tumor adjacent tissue. c Immunohistochemical staining pictures of ESCO2, CD3, CD4, CD8, CD274 in tumor tissue. More about this image found in Clinical Case. a Time axis of the patient’s visit experience and enhanced...

Fig. 9. In vitro experimental results. a Immunohistochemical results of correlation between ESCO2 and CD274. b Transwell invasion and migration assay of ESCO2-overexpressing and ESCO2 knockdown cells at ×200 magnification in the SW780 and MB49 cell lines. c Cell proliferation of SW780 cel... More about this image found in In vitro experimental results. a Immunohistochemical results of correlati...