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Keywords: VEGF
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Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2012) 84 (1): 22–31.
Published Online: 16 October 2012
...-vascular endothelial growth factor (VEGF) therapies for good- or intermediate-prognosis groups and anti-mammalian target of rapamycin (mTOR) for poor-risk patients. In the past years, biological changes leading to resistance to targeted agents have been widely investigated. Discoveries resulted...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2005) 69 (Suppl. 3): 25–33.
Published Online: 23 November 2005
...Michael S. Gordon; David Cunningham The anti-angiogenic agent bevacizumab (Avastin ® ) has been rationally designed to target vascular endothelial growth factor (VEGF), a key mediator of tumor angiogenesis. Based on its limited roles in adults, VEGF inhibition using bevacizumab would be expected...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2005) 69 (Suppl. 3): 11–16.
Published Online: 23 November 2005
...Napoleone Ferrara Tumors require nutrients and oxygen in order to grow, and new blood vessels, formed by the process of angiogenesis, provide these substrates. The key mediator of angiogenesis is vascular endothelial growth factor (VEGF), which is induced by many characteristics of tumors, most...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2005) 69 (Suppl. 3): 4–10.
Published Online: 23 November 2005
...Peter Carmeliet Vascular endothelial growth factor (VEGF) is a homodimeric glycoprotein with a molecular weight of approximately 45 kDa. It is the key mediator of angiogenesis (the formation of new blood vessels), and binds two VEGF receptors (VEGF receptor-1 and VEGF receptor-2), which...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2002) 64 (1): 61–73.
Published Online: 04 December 2002
... as a predictor of the invasive/metastatic potential and of the prognosis of advanced colorectal carcinoma (CRC) in relation to their intratumoral histologic heterogeneity. One hundred fifty two patients who had undergone surgical resection for advanced CRC entered this study. PD-ECGF, VEGF, and VEGF-C were...