... carcinoma Tyrosine-kinase inhibitor Sunitinib Targeted therapy First-line treatment Targeted therapies, directed against tumour angiogenesis and growth, offer substantial benefit for patients with metastatic renal cell carcinoma (mRCC), including prolonged progression-free survival (PFS...

...Jiro Okami; Kazuya Taniguchi; Masahiko Higashiyama; Jun Maeda; Kazuyuki Oda; Naoki Orita; Kyoko Koizumi; Ken Kodama; Kikuya Kato Background and Objectives: The association between epidermal growth factor receptor (EGFR) mutations and response to EGFR tyrosine kinase inhibitor (TKI) has been...

... from any ideas, methods, instructions or products referred to in the content or advertisements. HER EGFR Tyrosine-kinase inhibitor Tarceva TM Iressa TM PKI-166 CI-1033 Non-small cell lung cancer Head and neck cancer Ovarian cancer Members of the HER family of receptors...

..., instructions or products referred to in the content or advertisements. Receptor tyrosine kinases EGFR HER Targeted therapy Cancer Monoclonal antibodies Tyrosine-kinase inhibitor Gene therapy HER1 was discovered in the early 1980s and was the first molecule to be identified as a potential...