...Robert W. O’Donnell; Philip D. Noguchi; John C. Petricciani Organ cultures of chick and rabbit embryonic skin were used to assess the tumorigenicity of cultured human cell lines. Cell lines were from patients with (1) specific chromosomal abnormalities and an increased risk of cancer (Down’s...

...Michael Chopan; Levy Kopelovich This report describes the modulation of malignancy through coinoculation in vivo of a malignant mouse (A9) cell line, and a phenotypically stable, nontumorigenic hybrid clone derived from it by fusion with a transformed mutant human cell. Thus, the tumorigenicity...

...Kent L. Erickson; Funan Hu Somatic cell hybrids from viral fusions of murine melanoma (PAZG) × Chinese hamster peritoneal cells (CH) were compared with respect to surface antigenicity, karyotype and tumorigenicity. One line, F57-(9), which arose from the hybridization of two CH cells and one PAZG...

... by anti-α 5 and β 1 chain antibodies. BCS-TC2 cells are not tumorigenic in vivo, but are able to form tumors when coinjected with FN in nude mice. From these tumors, a tumorigenic cell subline (BCS-TC2.FN) was established. In vivo passaging of BCS-TC2.FN cells in the absence of FN allowed the selection...

...Yasushi Saga; Mitsuaki Suzuki; Natsuko Tamura; Michitaka Ohwada; Ikuo Sato A new cell line (SKS) established from ascites of a patient with neuroendocrine small cell carcinoma of the uterine cervix had a good tumorigenicity and caused marked peritoneal dissemination, and was also highly sensitive...