..., were typically managed surgically. However, as a result of the identification of activating mutations in the proto-oncogene KIT and the development of compounds that inhibit the KIT receptor tyrosine kinase, GISTs have, in the last 14 years, become the archetype of a targeted agent-responsive tumour...

..., instructions or products referred to in the content or advertisements. Targeted agents Prostate cancer Chemotherapy Hormonal therapy Prostate cancer is the most common cancer in men of age and the second most common cause of cancer-related male mortality, accounting for 10,000 deaths per year...