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Keywords: Tamoxifen
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Journal Articles
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2010) 77 (Suppl. 1): 23–37.
Published Online: 02 February 2010
.... Approximately 50% of patients with advanced disease do not respond to first-line treatment with tamoxifen, and many women who receive tamoxifen as adjuvant therapy experience tumor relapse and die from their disease. Aromatase inhibitors are proving superior to tamoxifen, at least in certain patient subsets...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1996) 53 (3): 175–181.
Published Online: 30 June 2009
...Masakuni Noguchi; David P. Rose; Itsuo Miyazaki We have reviewed the literature regarding the chemoprevention of breast cancer. Several clinical trials using retinoid, tamoxifen, or low-fat dietary intervention for the prevention of breast cancer are ongoing. In the next few years...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1994) 51 (1): 79–83.
Published Online: 30 June 2009
...Michael J. Millward; Ernst A. Lien; Angela Robinson; Brian M.J. Cantwell Tamoxifen and its principle metabolite N-desmethyltamoxifen can modulate multi-drug resistance in vitro. Tamoxifen 480 mg/day was given for 6 days with oral etoposide on days 4-6 to 17 patients with advanced solid tumours...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1997) 54 (5): 424–428.
Published Online: 30 June 2009
... pS2 expression may be inhibited by the antiestrogen tamoxifen (TAM) human breast cancer. pS2 expression was immunohistochemically investigated in 22 patients treated preoperatively with TAM and in 45 without TAM treatment (control group). Immunostaining was considered positive when 10% of tumor cells...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1991) 48 (3): 258–261.
Published Online: 26 June 2009
... upon the experimental cervical carcinogenesis observed in this mouse model system, the present study shows distinctly the modulatory effect of tamoxifen on the incidence of cervical carcinoma. Besides this, tamoxifen significantly lenghthens the latent period for both dysplasia and carcinoma...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1984) 41 (6): 387–392.
Published Online: 17 June 2009
...Rajendra G. Mehta; Wendy L. Cerny; Richard C. Moon Recently, several investigators have demonstrated the presence of triphenylethylene antiestrogen binding sites in the cytoplasm of many tissues, which specifically bind to radioactive tamoxifen with high affinity. Although mammary gland is one...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1982) 39 (3): 140–145.
Published Online: 11 June 2009
...Sewa S. Legha; George R. Blumenschein This papier reviews the different options of systemic therapy available for the management of patients with metastatic breast cancer. Endocrine therapy with tamoxifen, aminoglutethimide, progestins or androgens are useful for approximately one half...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1981) 38 (5): 281–285.
Published Online: 11 June 2009
...F. Boccardo; P. Bruzzi; A. Rubagotti; G. Nicolò; R. Rosso The action of prolonged administration of Tamoxifen on the vaginal epithelium in postmenopausal breast cancer patients has been investigated by means of exfoliative cytology. Our study gives quite convincing evidence of a clear-cut...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1983) 40 (4): 296–300.
Published Online: 11 June 2009
...Phyllis D. Williams; James P. Karr; Gerald P. Murphy High-dose tamoxifen citrate (80 mg/kg), or estradiol (100 μg/kg) was administered to intact or castrated Balb/C male and female mice with implanted murine renal cell adenocarcinoma. 100% tumor growth occurred, and tumor weights in tamoxifen...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1979) 36 (4): 149–155.
Published Online: 10 June 2009
... receptor binding of rat uterus. In addition, 1,2:5,6-dianhydrogalactitol, a highly active, proximal alkylating agent, applied in vitro did not alter the relative binding ability of tamoxifen to the cytoplasmic estradiol receptor of rat uterus and human breast cancer tissue. In summary, the present...