... used data from the Cancer Registry Database provided by the Cancer Center of Kaohsiung Veterans General Hospital to investigate whether AH use is associated with improved survival among patients with stage IV lung cancer. We analyzed AHs use across various patient subgroups, including sex, age...

... variables’ associations with overall survival (OS) and progression-free survival (PFS) were analyzed. Prognostic variables from univariate and multivariate analyses formed a baseline risk score. The score’s OS prediction was compared to standard CALGB and EORTC scores using ROC curves and Kaplan-Meier...

... Background: Esophageal squamous cell carcinoma (ESCC) is one of the most serious malignancies worldwide, seriously affecting the survival and living quality of patients. Abnormal expression of microRNAs plays a pivotal role in the development and progression of tumor, while exosomes are usually involved...

...-seminomatous germ cell tumors (NSGCTs) could be active surveillance (AS), chemotherapy, or retroperitoneal lymph node dissection. AS is the preferred option in most cases. The aim of this study was to evaluate long-term survival and prognostic factors in our population with AS approach. Methods: We collected...

... as prognostic factors for survival. For in vitro analysis, CD63 knockdown was performed in human ESCC cell lines (TE2 and TE15) using siRNA, and changes in proliferative potential. The gene expression change was also analyzed by microarray and gene set enrichment analysis. Results: Overall survival...

... characteristics and factors related to both PVT and survival. Methods: A large HCC database containing 1,094 patients with PVT and 2,513 patients without PVT was examined. Patients had routine baseline serum liver parameters and alpha-fetoprotein (AFP) levels measured, as well as radiological assessment...

...). More and more LABC patients are undergoing breast reconstruction after TM, but its long-term survival outcomes remain unclear. This study aimed to compare the survival outcomes of LABC patients who underwent breast reconstruction after TM with those who did not, based on a large sample. Methods: We...

... and October 2018. We assigned them to three groups according to age at HDT/ASCT: 60–64 years (S1), 65–69 years (S2) and ≥70 years (S3). We compared progression-free and overall survival, duration of hospitalization, complications, transfers to intermediate or intensive care unit, readmissions after discharge...

... (ICIs) combined with chemotherapy in these patients remains uncertain. Methods: We searched for studies published between randomized controlled trials of ICIs in combination therapies in advanced NSCLC patients post-EGFR TKI progression. Data on progression-free survival (PFS), overall survival (OS...

... of laryngocarcinoma cells. Results: High expression of SIA-IgG was associated with pT stage, pN stage, TNM stage, and recurrence during follow-up and was correlated with poor disease-free survival (DFS) and overall survival (OS). Multivariate Cox analysis demonstrated that SIA-IgG served as an independent risk factor...

... nsSNVs in cystic fibrosis transmembrane conductance regulator ( CFTR ) had significantly reduced disease-free (log rank, p = 0.002) and overall survival (log rank, p = 0.006). Conclusion: AI-driven in silico analysis with PGx data mining provided an effective approach navigating for functional...

...Patricia Toquero; Rebeca Mondéjar; Nuria Romero-Laorden; Elena Méndez; Lucía Castillo; Berta Hernández Marín; Olga Donnay; Ramon Colomer Introduction: Older patients (≤75 years) with advanced colorectal cancer (CRC) may have worse survival than non-older patients. We hypothesized that, rather than...

... were eligible for analysis. In 15 (18.5%) samples, tumors were positive for nectin-4. No significant associations were found for nectin-4 expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis disclosed a 5-year overall survival for nectin-4-negative and nectin-4-positive...

... been reported to be associated with prognosis in multiple cancers. This study aimed to investigate the association of polymorphisms in lipid metabolism pathway genes with survival outcomes in patients with surgically resected non-small cell lung cancer (NSCLC). Methods: In total, 744 patients...

... carcinoma, multiple serum parameters were evaluated for their relationship to survival. Methods: A prospectively collected database was interrogated of 487 patients with known hepatocellular carcinoma and documented survival and having all the inflammation parameters of interest in this study, together...

... < 0.001), and PNI ≥47 (HR, 0.333; 95% CI, 0.212–0.525; p < 0.001) were independently associated with overall survival. Multivariate analysis showed that an α-fetoprotein level ≥100 ng/mL (HR, 1.690; 95% CI, 1.316–2.170; p < 0.001) and PNI ≥47 (HR, 0.696; 95% CI, 0.528–0.918; p = 0.010) were...

... of this study is to review our experience for localized gastroesophageal adenocarcinoma in patients aged ≥80 years and to assess association between patient characteristics, clinical factors, and overall survival (OS) in order to optimize the therapeutic approaches for this population. Methods: Patients ≥80...

... with chemotherapy response and overall survival (OS) were analyzed in 314 lung adenocarcinoma patients who underwent PEM chemotherapy. Results: Among the SNPs investigated, 18 were significantly associated with response to chemotherapy, while 28 with OS. Of these SNPs, rs549794A>G in an enhancer which...

...Hyera Kim; Jin Young Kim; Keon Uk Park Introduction: Current standard chemotherapy for biliary tract cancer (BTC) has limited survival benefits, and the need for targeted therapies is increasing. This study investigated the genetic profiles and clinical implications of BRCA mutations in patients...

...: The prevalence of sarcopenia was 40.23%. Sarcopenia did not influence dose-limiting toxicity of treatment, hazard ratio (HR) 1.01, 95% CI (0.70–1.47). Sarcopenia was associated with lower progression-free survival (PFS): HR 1.49, 95% CI (0.98–2.26), and lower overall survival (OS): HR 1.67, 95% CI (1.11–2.52...