... and irradiation with X-rays, respectively. Results: High SIRT1 tissue expression was significantly associated with CRT resistance. Multivariate analysis identified high SIRT1 expression as an independent biomarker for poor CRT response. In TE-5 and TE-10 cells, SIRT1 knockdown significantly decreased cell...

...Bo Mi Ku; Yeon Jeong Kim; Donghyun Park; Se-Hoon Lee; Jin Seok Ahn; Keunchil Park; Myung-Ju Ahn; Jong-Mu Sun Objectives: During targeted therapy, tumor heterogeneity can drive the evolution of multiple tumor subclones harboring unique resistance mechanisms. Sequential profiling of plasma cell-free...

...Ekaterina Hanovich; Tim Asmis; Michael Ong; David Stewart Drug resistance is one of the most important factors limiting the success of systemic anticancer therapy in achieving cure or prolonged overall survival. In clinical practice, resistant disease describes cancer that is found to have...

... suppressor of esophageal squamous cell carcinoma (ESCC). Although a correlation between the epidermal differentiation gene and resistance to chemoradiotherapy (CRT) has been posited, no data regarding the ZNF750 status in ESCC have been reported. The aim of the present study was to evaluate the relationship...

...Jean-Yves Blay; Paolo G. Casali; Angelo Paolo Dei Tos; Axel Le Cesne; Peter Reichardt Gastrointestinal stromal tumour (GIST), while relatively rare, is the most common mesenchymal tumour of the gastrointestinal tract. These tumours are largely resistant to cytotoxic chemotherapy and, in the past...

... studies have provided more insight into different resistance mechanisms at the time of acquired resistance to TKIs. These mechanisms, as well as the role of rebiopsy in daily clinical practice, will subsequently be covered. Finally, treatment strategies for different types of progressive disease...

... mutational subtypes, particularly in patients with wild-type or KIT exon 9 genotype and against GISTs with secondary KIT exon 13 or 14 mutations. The choice between higher-dose imatinib and sunitinib after progression on standard dose imatinib is unclear, and apart from the GIST primary resistance genotype...

... transferase negative tumors causes cytotoxic lesions recognized by DNA mismatch repair, triggering apoptosis. Resistance (intrinsic or acquired) presents obstacles to successful temozolomide treatment, limiting drug efficacy and life expectancy. Two glioma cell lines, SNB19 and U373, sensitive to temozolomide...

...I. Fichtner; M. Becker; M. Lemm; G. Winterfeld A normally, relatively sensitive P 388 developed resistance within few passages (P 388/Mitox) by in vivo treatment with suboptimal doses (1 mg/kg i.v.) of mitoxantrone. This resistance remained stable over 50 generations without further drug treatment...

...Seema G. Pradhan; Vathsala S. Basrur; Manik P. Chitnis; Suresh H. Adwani The natural resistance of human chronic myeloid leukemia cells to adriamycin (ADR) was overcome by using the cell membrane modulator verapamil (VRP). The studies were done in vitro. [ 3 H] thymidine incorporation inhibition...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cell cycles Multiple drug therapy Resistance Oncology 26: 271-276 (1972) Expectations...

... experimenting stages. (2) Decrease in tumor growth and the appearance of a great chromosome number values dispersion, starting with the concentration of 275 μg/ml HC. (3) Tumor HC resistance, biologically characterized by a return to a high rate of growth and genetically by the presence of a heteroploid cell...

.... In spite of their impressive results, a significant fraction of patients still develop either primary or secondary resistance, a fact that entails the discussion of possible mechanisms of resistance. Biomarkers including PTEN, p95HER2, IGF1R and others have been linked to response to Her-2/neu-targeting...

...Hiroaki Itamochi; Junzo Kigawa; Ryoji Akeshima; Shinya Sato; Shunji Kamazawa; Masakuni Takahashi; Yasunobu Kanamori; Mitsuaki Suzuki; Michitaka Ohwada; Naoki Terakawa Resistance of clear cell carcinoma (CCC) of the ovary to platinum-based chemotherapy is associated with a poor prognosis. However...

...Gábor Pogány; Ferenc Timár; Júlia Oláh; Revekka Harisi; Gábor Polony; Sándor Paku; József Bocsi; András Jeney; Gordon W. Laurie Objectives and Methods: Tumor dormancy and resistance to cytotoxic agents are key limiting events in the treatment of malignant diseases. To determine whether both...

... be effective for the treatment of hormone-refractory breast cancer. 25 8 2000 Breast cancer Antiestrogen Medroxyprogesterone acetate Resistance Vascular endothelial growth factor Angiogenesis Apoptosis TNP-470 The VEGF concentrations in the culture medium were measured...

...Jun-ichi Kurebayashi; Takemi Otsuki; Shigeru Yamamoto; Masafumi Kurosumi; Taisuke Nakata; Shiro Akinaga; Hiroshi Sonoo The critical mechanisms responsible for antiestrogen resistance have not yet been elucidated. We previously established a breast cancer cell line, KPL-1, derived from a patient...