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Keywords: RET
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Journal Articles

Comprehensive Genomic Profiling of Clinically Advanced Medullary Thyroid Carcinoma

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Subject Area:
Topic Article Package: Pharmacology 2016 , Oncology
Andreas M. Heilmann, Vivek Subbiah, Kai Wang, James X. Sun, Julia A. Elvin, Juliann Chmielecki, Steven I. Sherman, Ravi Murthy, Naifa L. Busaidy, Ishwaria Subbiah, Roman Yelensky, Chaitali Nangia, Jo-Anne Vergilio, Saad A. Khan, Rachel L. Erlich, Doron Lipson, Jeffrey S. Ross, Vincent A. Miller, Manisha H. Shah, Siraj M. Ali, Philip J. Stephens
Journal: Oncology
Oncology (2016) 90 (6): 339–346.
https://doi.org/10.1159/000445978
Published Online: 21 May 2016
... consecutive medullary thyroid carcinoma cases to identify all four classes of genomic alterations, and outcome for an index patient was collected. Results: RET was mutated in 88% (30/34) of cases, with RET M918T being responsible for 70% (21/30) of the RET alterations. The other RET alterations were RET...
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Journal Articles

5′-End RET Splicing: Absence of Variants in Normal Tissues and Intron Retention in Pheochromocytomas

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Subject Area:
Oncology
Hervé Le Hir, Nicolas Charlet-Berguerand, Vittorio de Franciscis, Claude Thermes
Journal: Oncology
Oncology (2002) 63 (1): 84–91.
https://doi.org/10.1159/000065725
Published Online: 16 August 2002
...Hervé Le Hir; Nicolas Charlet-Berguerand; Vittorio de Franciscis; Claude Thermes The Ret tyrosine kinase is implicated in neuronal cell survival, kidney development and tumorigenesis. Several 3′ and 5′ transcript variants have been described resulting from alternative splicing of the RET pre-mRNA...
View article titled, 5′-End RET Splicing: Absence of Variants in Normal Tissues and Intron Retention in Pheochromocytomas
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Journal Articles

Relative Expression of the RET9 and RET51 Isoforms in Human Pheochromocytomas

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Subject Area:
Oncology
Hervé Le Hir, Nicolas Charlet-Berguerand, Anne-Paule Gimenez-Roqueplo, Massimo Mannelli, Pierre-François Plouin, Vittorio de Franciscis, Claude Thermes
Journal: Oncology
Oncology (2000) 58 (4): 311–318.
https://doi.org/10.1159/000012118
Published Online: 18 May 2000
...Hervé Le Hir; Nicolas Charlet-Berguerand; Anne-Paule Gimenez-Roqueplo; Massimo Mannelli; Pierre-François Plouin; Vittorio de Franciscis; Claude Thermes Activating mutations of the RET oncogene cause the inheritance of multiple endocrine neoplasia type 2 (MEN2). The RET pre-mRNA is spliced...
View article titled, Relative Expression of the RET9 and RET51 Isoforms in Human Pheochromocytomas
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