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1-12 of 12
Keywords: P-glycoprotein
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Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (1997) 54 (3): 231–237.
Published Online: 30 June 2009
...Kijuro Takanishi; Masaru Miyazaki; Masayuki Ohtsuka; Nobuyuki Nakajima Hepatocellular carcinomas (HCCs) from 31 patients, cirrhotic livers from 7 patients and normal liver from 8 patients were immunohistochemically assessed in frozen sections using anti-P-glycoprotein (Pgp) monoclonal antibody C219...
Journal Articles
Subject Area:
Oncology
Tsukasa Hotta, Hiroshi Tanimura, Hiroki Yamaue, Makoto Iwahashi, Masaji Tani, Takuya Tsunoda, Mikiko Tamai, Kohei Noguchi, Shizuma Mizobata, Kazuo Arii, Hiroshi Terasawa
Journal:
Oncology
Oncology (1997) 54 (2): 153–157.
Published Online: 30 June 2009
...Tsukasa Hotta; Hiroshi Tanimura; Hiroki Yamaue; Makoto Iwahashi; Masaji Tani; Takuya Tsunoda; Mikiko Tamai; Kohei Noguchi; Shizuma Mizobata; Kazuo Arii; Hiroshi Terasawa Resistance to doxorubicin (DOX) is mainly due to the effect of P-glycoprotein encoded by the multidrug resistance (MDR) gene...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (1997) 54 (5): 391–399.
Published Online: 30 June 2009
...Naomi Monden; Shun’ichi Abe; Ichiro Sutoh; Yoshitaka Hishikawa; Shoichi Kinugasa; Naofumi Nagasue Although experimental studies indicate that overexpression of metallothionein (MT), glutathione-S-transferase-π; (GST-π;), or P-glycoprotein (P-GP) is related to the drug resistance of cancer cells...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (1994) 51 (1): 2–8.
Published Online: 30 June 2009
... intracellular [ 3 H]vincristine with concurrent increase in the expression of a 170-kDa membrane glycoprotein (P-glycoprotein) suggested a plausible underlying mechanism for the development of resistance. Amplification of the mdr 1gene as well as a homogeneous staining region on the long arm of the 7th...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (1994) 51 (5): 440–445.
Published Online: 30 June 2009
... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. MDR1 gene P-glycoprotein Vindesine Esophageal carcinoma SH-1...
Journal Articles
Subject Area:
Oncology
Stefan Duensing, Iris Dallmann, Jens Grosse, Jan Buer, Enrique Lopez Hänninen, Markus Deckert, Stephan StÖrkel, Hartmut Kirchner, Hubert Poliwoda, Jens Atzpodien
Journal:
Oncology
Oncology (1994) 51 (4): 309–313.
Published Online: 30 June 2009
...Stefan Duensing; Iris Dallmann; Jens Grosse; Jan Buer; Enrique Lopez Hänninen; Markus Deckert; Stephan StÖrkel; Hartmut Kirchner; Hubert Poliwoda; Jens Atzpodien We evaluated 28 patients with advanced renal cell carcinoma for the initial expression of P-glycoprotein (MDR1 gene product) employing...
Journal Articles
Subject Area:
Oncology
Anne O’Meara, Atsushi Imamura, Pauline Johnson, Raymond Ball, Sean Rooney, Barry Kierce, Takashi Tsuruo, Peter Dervan
Journal:
Oncology
Oncology (1992) 49 (3): 203–208.
Published Online: 26 June 2009
...Anne O’Meara; Atsushi Imamura; Pauline Johnson; Raymond Ball; Sean Rooney; Barry Kierce; Takashi Tsuruo; Peter Dervan P-Glycoprotein (P-gp), the product of the mdr-1 gene, is implicated in the development of chemoresistance in a variety of, mostly adult, cancers. Its role in paediatric tumours...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (1993) 50 (4): 303–308.
Published Online: 26 June 2009
.... P-glycoprotein Multidrug-resistance Monoclonal antibodies Immunotoxins Antisense oligodeoxynucleotides T. Efferth M. Volm German Cancer Research Centre. Heidelberg. FRG Original Paper Oncology 1993:50:303 308 Modulation of P-GlycoproteinMediated Multidrug Resistance by Monoclonal Antibodies...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2007) 71 (3-4): 292–296.
Published Online: 23 July 2007
... determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. P-glycoprotein expression was assessed using standard Western blotting techniques. Results: Patupilone was found to be the most potent drug in all 8 HCC cell lines. All cell lines except SNU-449 were 4- to19-fold more...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2007) 70 (6): 403–410.
Published Online: 23 February 2007
...In-Ju Kim; Young-Tae Bae; Seong-Jang Kim; Yong-Ki Kim; Dong-Soo Kim; Jung Sub Lee Purpose: To determine and predict P-glycoprotein (Pgp) and multidrug-resistance-related protein (MRP) expression in untreated breast cancer patients by visual and quantitative indices of double-phase 99m Tc MIBI...
Journal Articles
Subject Area:
Oncology
Masahiko Ohsawa, Yoshihiro Ikura, Hiroko Fukushima, Nobuyuki Shirai, Yoshimi Sugama, Takehisa Suekane, Michihiko Hirayama, Masayuki Hino, Makiko Ueda
Journal:
Oncology
Oncology (2005) 68 (4-6): 422–431.
Published Online: 17 August 2005
...Masahiko Ohsawa; Yoshihiro Ikura; Hiroko Fukushima; Nobuyuki Shirai; Yoshimi Sugama; Takehisa Suekane; Michihiko Hirayama; Masayuki Hino; Makiko Ueda Background/Aims: The aim of this study was to determine whether expression of P-glycoprotein (P-gp), multidrug-resistance-related protein 1 (MRP1...
Journal Articles
Subject Area:
Oncology
Wu-Huei Hsu, Ruoh-Fang Yen, Chia-Hung Kao, Shih-Chih Shiun, Nan-Yung Hsu, Cheng-Chieh Lin, Cheng-Chun Lee
Journal:
Oncology
Oncology (2002) 63 (2): 173–179.
Published Online: 16 September 2002
... of P-glycoprotein (Pgp) expression and response to paclitaxel in non-small-cell lung cancer (NSCLC). Methods: Before chemotherapy with paclitaxel, 30 patients with stage IIIb or IV NSCLC were enrolled in this study. Early chest SPECT was performed 10 min after intravenous injection of Tc-MIBI. Tc-MIBI...