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Keywords: P-glycoprotein
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Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1997) 54 (2): 153–157.
Published Online: 30 June 2009
...Tsukasa Hotta; Hiroshi Tanimura; Hiroki Yamaue; Makoto Iwahashi; Masaji Tani; Takuya Tsunoda; Mikiko Tamai; Kohei Noguchi; Shizuma Mizobata; Kazuo Arii; Hiroshi Terasawa Resistance to doxorubicin (DOX) is mainly due to the effect of P-glycoprotein encoded by the multidrug resistance (MDR) gene...
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1994) 51 (1): 2–8.
Published Online: 30 June 2009
... intracellular [ 3 H]vincristine with concurrent increase in the expression of a 170-kDa membrane glycoprotein (P-glycoprotein) suggested a plausible underlying mechanism for the development of resistance. Amplification of the mdr 1gene as well as a homogeneous staining region on the long arm of the 7th...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1994) 51 (5): 440–445.
Published Online: 30 June 2009
... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. MDR1 gene P-glycoprotein Vindesine Esophageal carcinoma SH-1...
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1992) 49 (3): 203–208.
Published Online: 26 June 2009
...Anne O’Meara; Atsushi Imamura; Pauline Johnson; Raymond Ball; Sean Rooney; Barry Kierce; Takashi Tsuruo; Peter Dervan P-Glycoprotein (P-gp), the product of the mdr-1 gene, is implicated in the development of chemoresistance in a variety of, mostly adult, cancers. Its role in paediatric tumours...
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2007) 71 (3-4): 292–296.
Published Online: 23 July 2007
... determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. P-glycoprotein expression was assessed using standard Western blotting techniques. Results: Patupilone was found to be the most potent drug in all 8 HCC cell lines. All cell lines except SNU-449 were 4- to19-fold more...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2002) 63 (2): 173–179.
Published Online: 16 September 2002
... of P-glycoprotein (Pgp) expression and response to paclitaxel in non-small-cell lung cancer (NSCLC). Methods: Before chemotherapy with paclitaxel, 30 patients with stage IIIb or IV NSCLC were enrolled in this study. Early chest SPECT was performed 10 min after intravenous injection of Tc-MIBI. Tc-MIBI...