... was to investigate gender-specific aspects in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (ASCT). Methods: A retrospective data analysis of 191 patients with MM who underwent ASCT was performed. Data collected from clinical records included age, sex, stage, induction therapy...

...) is the standard of care for selected patients with multiple myeloma (MM). Many data exist on ASCT in the era of novel agents. We retrospectively analyzed 189 patients (108 males and 81 females) with biopsy-proven MM, who had received ASCT after induction therapy with either conventional chemotherapy alone...

...)] to determine whether the addition of lenalidomide maintenance therapy for primary treatment of multiple myeloma is cost-effective. We used progression-free survival and adverse event data from the MM-015 study for the analysis. Two novel measures of cost-effectiveness termed the Average Cumulative Cost per...

...W. Lamm; B. Drach-Schauer; S. Eder; J. Drach Objective: Bortezomib (Btz) has emerged as a standard of care in the treatment of patients with multiple myeloma (MM), but Btz-induced peripheral neuropathy (PNP) has a particularly negative impact on patients' quality of life. According to a recent...

...Akio Urabe Interferon (IFN) has diverse acitvities against the proliferation and function of various tumor cells. Recently, IFN-α has been widely used in the treatment of several hematological malignancies including chronic myelogenous leukemia (CML), multiple myeloma, and hairy cell leukemia. IFN...

... g/kg raised all 12 antibodies in 53–73% of CLLpatients when assessments were made after each infusion. In multiple myeloma (MM) patients, 73–82% and 73–91 % of patients had increased antibody levels, respectively, before and after the 4th–6th infusions at the 0.8 g/kg dose level. However, in only 45...

...Sz. Ottó; Zsuzsa Végh; I. Hindy; Ilona Péter Double (χ + λ ), Bence Jones (BJ) proteinuria was detected in a male patient of 73 years. The disease started as a solitary plasmacytoma in bone and transformed into multiple myeloma. At the beginning, isolated BJ λ proteinuria was observed which...

...Jeffrey L. Spiess; David J. Adelstein; John D. Hines The clinical features, treatment, and course of 6 patients with multiple myeloma, who presented initially with spinal cord compression, are reviewed. These 6 represent 12% of all patients with myeloma seen at our institution since 1979. Eighty...

...Nancy Litton; Mehdi Zarabi An unusual combination of renal oncocytoma with multiple myeloma in a 69-year-old woman is reported. The possible hematogenous spread and/or direct extension of malignant plasma cells to the kidney tumor is discussed. 25 6 2009 © 1988 S. Karger AG, Basel 1988...

...Regis Bataille; Philippe Dessauw; Jacques Sany Polyclonal immunoglobulins (Ig) were measured at diagnosis and/or following chemotherapy in 226 patients with a malignant plasma cell dyscrasia (PCD), including 11 patients with solitary myeloma (SM) and 215 patients with multiple myeloma (MM...

...H. Ludwig; A. Cortelezzi; B.G.K. Van Camp; E. Polli; W. Scheithauer; R. Kuzmits; W. Linkesch; H. Gisslinger; H. Sinzinger; E. Fritz; R. Flener Forty-two patients with multiple myeloma were allocated to two groups to receive either polychemotherapy with vincristine, melphalan, cyclophosphamide...

...’ might impede the development of metastases to bone or their local extension. Fetal rat bones prelabelled with 45 Ca were cultured in the presence of 10 –– 7 M prostaglandin E 2 , sera from normal individuals, or from patients with multiple myeloma. Additional samples preincubated for 3 h with 1 μ g/ml...

...Baku S. Shaikh; Robert M. Lombard; Peter C. Appelbaum; Michael S. Bentz A total of 59 infections were encountered in 29/46 patients with multiple myeloma (MM). Most infections arose in the urinary tract (31%), respiratory tract (29%), followed by blood (12%), oropharynx (12%), skin and soft tissue...

... of phosphohexoseisomerase (PHI) in 11 multiple myeloma patients before treatment and in another group of 11 patients undergoing polychemotherapy treatment. From all patients, under the same standard conditions, 6 venous samples were taken at 4-hour intervals starting at 08.00 h, for a day. PHI serum levels were determined...

...Basil S. Kasimis; Ruey Yen-Lin; Richard S. Neiman A case of multiple myeloma associated with myelofibrosis and myeloid metaplasia is reported. The presentation of our patient and a detailed review of the current literature suggest that more than a chance relationship exists between the two...

.... Oncology 37: 411-417 (1980) Hormonal Effects upon the Rate of Proliferation of the Murine Plasmacytoma MOPC 3151 Anthony K. Chan, Jerome M. Davis and E. Aubrey Thompson Department of Biology, University of South Carolina. Columbia, S. C. Key Words. Plasmacytoma growth Multiple myeloma Hormones...

...R.K. Mohindra; M. Al-Sarraf Seventeen cancer patients with monoclonal gammapathy on serum protein electrophoresis are described. Thirteen of these patients were proved to have multiple myeloma, while four patients had "benign" monoclonal gammapathy. In all the cases where bone marrow aspiration...

...H. McLaughlin; Mary Melinn; P.A. Farrelly A patient with both chronic lymphatic leukemia and multiple myeloma is presented. Characterisation of the leukemic cells showed them to possess Fc receptors but to lack SmlG and C3 receptors. Intracellular immunoglobulin was not detected within the leukemic...

...I.P. Law; J. Blom Seven patients with multiple myeloma who developed a second neoplasm are presented. There were four patients with acute leukemia and three patients with non-hematologic neoplasms. The patients with acute leukemia were among the longest survivors (median duration ≈ 72 months...

...Stanley C. Deresinski; David A. Stevens A patient with disseminated herpes simplex virus infection, documented by direct immunofluorescence, and untreated multiple myeloma with abnormal immunoglobulins is presented. Reports of infections with intracellular pathogens in myeloma patients are rare...