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1-4 of 4
Keywords: Mismatch repair
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Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2014) 88 (1): 28–48.
Published Online: 26 September 2014
... and functional mismatch repair (MMR); resistance, conferred by MGMT or MMR deficiency, represents a barrier to successful treatment. TMZ analogs were synthesized, substituting N3-methyl with propargyl ( 1 ) or sulfoxide ( 2 ). MTT assays were conducted in SNB19 and U373 isogenic glioma cell lines (V = vector...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2010) 78 (2): 103–114.
Published Online: 31 March 2010
... transferase negative tumors causes cytotoxic lesions recognized by DNA mismatch repair, triggering apoptosis. Resistance (intrinsic or acquired) presents obstacles to successful temozolomide treatment, limiting drug efficacy and life expectancy. Two glioma cell lines, SNB19 and U373, sensitive to temozolomide...
Journal Articles
Subject Area:
Oncology
Kazuki Taniguchi, Shizuko Kakinuma, Yutaka Tokairin, Masami Arai, Hiroyuki Kohno, Keiji Wakabayashi, Tatsuhiko Imaoka, Eisaku Ito, Morio Koike, Hiroyuki Uetake, Mayumi Nishimura, Kazumi Yamauchi, Ken-ichi Sugihara, Yoshiya Shimada
Journal:
Oncology
Oncology (2007) 71 (1-2): 124–130.
Published Online: 13 April 2007
... silencing of Mlh1 , plays a key role in the pathogenesis of colorectal cancer. The interaction between inflammation and mismatch repair deficiency, however, remains unclear. The aim of this study was to determine the effect of inflammation on colorectal carcinogenesis in Mlh1 -deficient mice. Method...
Journal Articles
Subject Area:
Oncology
Ramon Martinez, Hans-K. Schackert, Jens Plaschke, Gustavo Baretton, Hella Appelt, Gabriele Schackert
Journal:
Oncology
Oncology (2004) 66 (5): 395–403.
Published Online: 02 September 2004
... (MSI) plays a pathogenic role in sporadic cancers such as colon, gastric and endometrial carcinomas with deficient mismatch repair (MMR). We aimed to perform a comprehensive analysis of the relationship between CIN and MSI mechanisms in sporadic glioblastomas. Methods: 129 GBMs were examined (109 newly...