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1-17 of 17
Keywords: Microsatellite instability
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Journal Articles
Subject Area:
Oncology
Guang Yang, Takehiro Tanaka, Hideaki Kinugasa, Hiromitsu Kanzaki, Meng-Xi Chen, Koichi Ichimura, Masahiro Nakagawa, Zai-Shun Jin, Ru-yi Zheng, Tadashi Yoshino
Journal:
Oncology
Oncology (2022) 100 (5): 290–302.
Published Online: 29 March 2022
... for this disease, they remain controversial due to their rarity. In this study, we retrospectively analyzed 54 cases of invasive NADA, focusing on the microsatellite instability (MSI) phenotype, programmed cell death-ligand 1 (PD-L1) expression, and prognostic factors. Methods: Expression of the PD-L1 protein...
Journal Articles
Subject Area:
Oncology
Hyae Min Jeon, Jae Seok Lee, Soo Hee Kim, Kum-Hee Yun, Kyu Hyun Park, Min Kyung Jeon, Young Han Lee, Hong In Yoon, Jin-Suck Suh, Hyuk Hur, Kyung Sik Kim, Sunghoon Kim, Seung Hyun Kim, Hyo Song Kim
Journal:
Oncology
Oncology (2020) 98 (11): 817–826.
Published Online: 04 September 2020
... assessed the molecular targets programmed death ligand 1 (PD-L1), microsatellite instability (MSI), and PIK3CA . Seventy-four patients with liposarcomas who underwent curative resection were assessed for PD-L1 expression in the tumor and tumor-infiltrating lymphocytes (TILs), mismatch repair proteins (MLH1...
Journal Articles
Subject Area:
Oncology
Jing Zhou, Zhengyi Zhao, Yuzi Zhang, Celimuge Bao, Longgang Cui, Shangli Cai, Yuezong Bai, Lin Shen, Xiaotian Zhang
Journal:
Oncology
Oncology (2020) 98 (8): 583–588.
Published Online: 10 June 2020
... pathway Microsatellite instability Gastric cancer (GC) is a highly aggressive type of cancer, and around half of the GC-related deaths occur in China [ 1 ]. Previous studies revealed that aggregation within families occurred in a sizable fraction (∼10%) of the GC patients [ 2 ]. The approval...
Journal Articles
Subject Area:
Oncology
Rosalba Miceli, Jiyeong An, Maria Di Bartolomeo, Federica Morano, Seung Tae Kim, Se Hoon Park, Min Gew Choi, Joon Ho Lee, Alessandra Raimondi, Giovanni Fucà, Tae Sung Sohn, Jae Moon Bae, Sung Kim, Do Hoon Lim, Won Ki Kang, Kyoung-Mee Kim, Filippo Pietrantonio, Jeeyun Lee
Journal:
Oncology
Oncology (2019) 97 (1): 38–43.
Published Online: 02 May 2019
... patients with microsatellite instability (MSI)-high gastric cancer (GC) may have better prognosis but worse outcomes. Objective: Here we explored the prognostic role of MSI in Asian patients. Methods: This post hoc analysis comprehended radically resected GC patients randomized to XP (capecitabine...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2016) 91 (5): 289–294.
Published Online: 28 September 2016
... in colorectal (CRC) and gastric (GC) cancers. Methods: There are mononucleotide repeats in EGR1 and BRSK1 , which could be mutated in cancers with defects in mismatch repair, resulting in microsatellite instability (MSI). We analyzed 124 CRCs and 79 GCs for mutations and their intratumoral heterogeneities (ITHs...
Journal Articles
Subject Area:
Oncology
Misato Amaki-Takao, Tatsuro Yamaguchi, Soichiro Natsume, Takeru Iijima, Rika Wakaume, Keiichi Takahashi, Hiroshi Matsumoto, Michiko Miyaki
Journal:
Oncology
Oncology (2016) 91 (3): 162–170.
Published Online: 13 July 2016
... of colorectal cancers with BRAF D594G mutations. Methods: We selected 908 colorectal cancer patients who underwent surgical resection from January 2008 to January 2013, and assessed BRAF , KRAS , microsatellite instability, and CpG island methylator phenotype (CIMP). Results: We detected BRAF D594G in 7...
Journal Articles
Subject Area:
Oncology
Izaskun Rubio, Eduardo Ibáñez-Feijoo, Leire Andrés, Elena Aguirre, Judith Balmaña, Pilar Blay, Gemma Llort, Santiago González-Santiago, Hiart Maortua, Maria Isabel Tejada, Cristina Martinez-Bouzas
Journal:
Oncology
Oncology (2016) 91 (3): 171–176.
Published Online: 12 July 2016
.... In blood samples obtained, we analyzed mutations in mismatch repair (MMR) genes, as well as protein expression by immunohistochemistry and microsatellite instability (MSI) in tumour tissue. Results: A total of 103 patients were enrolled. We detected 14 pathogenic mutations and 4 genetic variants of unknown...
Journal Articles
Subject Area:
Oncology
Wen-Jian Meng, Xiao-Feng Sun, Chao Tian, Ling Wang, Yong-Yang Yu, Bing Zhou, Jun Gu, Qing-Jie Xia, Yuan Li, Rong Wang, Xue-Lian Zheng, Zong-Guang Zhou
Journal:
Oncology
Oncology (2007) 72 (1-2): 82–88.
Published Online: 14 November 2007
...Wen-Jian Meng; Xiao-Feng Sun; Chao Tian; Ling Wang; Yong-Yang Yu; Bing Zhou; Jun Gu; Qing-Jie Xia; Yuan Li; Rong Wang; Xue-Lian Zheng; Zong-Guang Zhou Objectives: Tumors with high-frequency microsatellite instability (MSI-H) have unique biological behavior and the predictive role of microsatellite...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2005) 68 (4-6): 548–557.
Published Online: 17 August 2005
... Cancer Institute Workshop on Microsatellite Instability (BAT25, BAT26, D5S346, D2S123, D17S250) were used in this study [ 19 ]. Products were run on an ABI 373A fluorescent DNA sequencer. PCR conditions are described elsewhere [ 9 ]. MSI was defined as the presence of an additional peak [ 9 ]. A tumor...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2003) 65 (4): 347–354.
Published Online: 15 January 2004
...Britta Kleist; Dirk Junghans; Gerd Lorenz; Alexander Bankau; Micaela Poetsch Objectives: MIB-1 and p53 protein expression, loss of heterozygosity (LOH), microsatellite instability (MSI) of di- and mononucleotide repeats, and HPV status were tested for their potential to characterize different...
Journal Articles
Subject Area:
Oncology
Koshi Mimori, Hiroshi Inoue, Takeshi Shiraishi, Ayumi Matsuyama, Ken-ichi Mafune, Yoichi Tanaka, Masaki Mori
Journal:
Oncology
Oncology (2003) 64 (3): 275–279.
Published Online: 21 April 2003
... the effect of an allelic loss of the FHIT gene on esophageal cancer when coupled with a deficient mismatch repair system. In this study, 8 of 42 patients with esophageal cancer had microsatellite instability (MSI), and 29 cases demonstrated allelic loss (loss of heterozygosity or homozygous deletion...
Journal Articles
Subject Area:
Oncology
Cathy Wang, Marius van Rijnsoever, Fabienne Grieu, Sean Bydder, Hany Elsaleh, David Joseph, Jennet Harvey, Barry Iacopetta
Journal:
Oncology
Oncology (2003) 64 (3): 259–265.
Published Online: 21 April 2003
... run on silver stain SSCP gels, the mutant bands excised, reamplified by PCR and then used as template for DNA sequencing in order to confirm the type of mutation [ 25 ]. Although microsatellite instability (MSI+) is generally thought to be a marker of good prognosis in CRC, several studies have...
Journal Articles
Subject Area:
Oncology
Hiroshi Saeki, Shinji Tanaka, Eriko Tokunaga, Hidetoshi Kawaguchi, Yoichi Ikeda, Yoshihiko Maehara, Keizo Sugimachi
Journal:
Oncology
Oncology (2001) 61 (2): 156–161.
Published Online: 22 August 2001
... of the targets of microsatellite instability (MSI) in colorectal cancers in with MSI. We carried out a sequencing analysis of the Tcf-4 gene in 41 Japanese patients with gastrointestinal tumors with MSI as well as in cancer cell lines. Three of 21 (14.3%) colorectal tumors with MSI contained a mutant Tcf-4 gene...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2000) 58 (4): 305–310.
Published Online: 18 May 2000
...Tadeusz Dobosz; Tadeusz Łukienczuk; Maria Sąsiadek; Anna Kuczyńska; Ewa Jankowska; Nikolaus Blin Microsatellite instability (MSI) is a molecular landmark of mutations in DNA mismatch repair genes. The impaired efficiency of DNA repair mechanisms promotes carcinogenesis as well as contributes...
Journal Articles
Subject Area:
Oncology
Journal:
Oncology
Oncology (2000) 58 (2): 159–160.
Published Online: 23 February 2000
... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Wilms’ tumor Colon cancer Microsatellite instability Hereditary nonpolyposis colorectal cancer Although...
Journal Articles
Subject Area:
Oncology
Hany Elsaleh, Brenda Powell, Prinya Soontrapornchai, David Joseph, Fabrizio Goria, Nigel Spry, Barry Iacopetta
Journal:
Oncology
Oncology (2000) 58 (1): 52–59.
Published Online: 14 January 2000
...Hany Elsaleh; Brenda Powell; Prinya Soontrapornchai; David Joseph; Fabrizio Goria; Nigel Spry; Barry Iacopetta Two common genetic alterations in colon carcinoma, p53 mutation and microsatellite instability (MSI), were investigated to determine their prognostic importance for cancer-specific...
Journal Articles
Subject Area:
Oncology
Masatoshi Watanabe, Taizo Shiraishi, Tsuyoshi Muneyuki, Moritaka Nagai, Kazuo Fukutome, Mariko Murata, Jyuichi Kawamura, Ryuichi Yatani
Journal:
Oncology
Oncology (1998) 55 (6): 569–574.
Published Online: 22 October 1998
...Masatoshi Watanabe; Taizo Shiraishi; Tsuyoshi Muneyuki; Moritaka Nagai; Kazuo Fukutome; Mariko Murata; Jyuichi Kawamura; Ryuichi Yatani A series of 25 primary prostate cancers in Japanese were screened for loss of heterozygosity and microsatellite instability using twelve microsatellite markers...