...Syed A.A. Rizvi; Yasser Shahzad; Ayman M. Saleh; Nawshad Muhammad In this review, human methotrexate dosing regimens, as well as their relationship to data from in vitro cell culture and in vivo animal and human studies, are discussed. Low-dose, intermediate-dose, and high-dose therapies...

...-hour intravenous (i.v.) infusion of methotrexate (MTX), 250 mg/m 2 , followed 24 h later by a 2-hour i.v. infusion of L -folinic acid (LFA), 250 mg/m 2 , and 5-fluorouracil (FU), 600 mg/m 2 as an i.v. bolus. Only 1 previously untreated patient obtained a partial response. The MTX serum level assessed...

... towards a higher prevalence of subclinical tubular changes was observed in patients with higher cumulative doses of methotrexate or ifosfamide and in patients with combined Ctx and Rtx with radiation fields involving the renal area. Changes in glomerular function were not observed. It is concluded...

...K.P. Fung; W.P. Lam; Y.M. Choy; C.Y. Lee Methotrexate (MTX) suppressed the growth of Ehrlich ascites tumor (EAT) cells in vitro. The intracellular level of phosphoribosyl 5-pyrophosphate (PRPP) of EAT cells increased in a dose-dependent manner in response to MTX treatment. At the same time...

...G. Samonis; D. Bafaloukos; A.N. Margioris; G. Katsarma; P. Toloudis; C. Bacoyannis; N. Karvounis; V. Georgoulias; P. Kosmidis Fifty-one patients with advanced breast cancer entered a prospective study of combination chemotherapy, consisting of mitoxantrone (10 mg/m 2 ), methotrexate (30 mg/m 2...

... to either methotrexate (10 -6 -10 -4 M ), doxorubicin (10 -7 -10 -5 M ) or mitoxantrone (10 -7 -10 -5 M). In HPMC exposed to doxorubicin (10 -6 M ) the intracellular transport of potassium, as assessed with 86 Rb as its analogue, was not affected. Methotrexate (10 -5 M ) diminished Na, K-ATPase activity...

...Hiltje de Graaf; Pax H.B. Willemse; Barbara Bong; Henk Piersma; Tonnis Tjabbes; Henk van Veelen; Jules L.L.M. Coenen; Elisabeth G.E. de Vries The effects of granulocyte colony-stimulating factor (G-CSF) on total dose and dose intensity of standard oral adjuvant CMF (cyclophosphamide, methotrexate...

...Rudiger E. Port; Barbel Daniel; Reinhard W. Ding; Richard Herrmann The pharmacokinetics of 5-fluorouracil (FU) has been investigated in 26 cancer patients; 15 of these patients were pretreated with methotrexate (MTX). FU was given by a constant rate intravenous infusion within lOmin, at doses...

...Pratima Sur; Yoshinobu Matsuo; Takeshi Otani; Jun Minowada The effect of a- and γ-interferon on methotrexate cytotoxicity against human promyelocytic cell line HL-60 has been evaluated. Synergistic inhibition of proliferation is observed with the combination of methotrexate and γ-interferon...

... the CMF (cyclophosphamide, methotrexate and 5-fluorouracil) combination chemotherapy. The MCP and DXM dosage were: 2 × 2 mg/kg and 2 × 0.2 mg/kg, respectively. In 41 % of eighty evaluable courses, nausea and vomiting were eliminated altogether. The common side effects were: drowsiness, restlessness...

...Gritta E. Janka; Reinhold Mack; Magdalena Helmig; Rainer J. Haas; Frank Bidlingmaier In 86 children with acute lymphocytic leukemia (ALL) and in 6 children with medulloblastoma 253 24-hour methotrexate (MTX) infusions with 150, 500, and 700 mg/m2 were performed. MTX concentrations in plasma...

...Gerald P. Murphy; Edson Pontes; Phyllis D. Williams A murine bladder tumor model was evaluated for tumor growth retardation while receiving combination chemotherapy, either 40 mg/m 2 methotrexate and 35 mg/m 2 cis-platinum or 500 mg/m 2 Cytoxan and 35 mg/m 2 cis-platinum at 3-week intervals. Tumor...

...Henning Breithaupt; Eberhard Küenzlen 9 patients with osteosarcoma were treated with a total of 122 infusions of high-dose methotrexate (MTX; 140–350 mg/kg) followed by leucovorin rescue. Plasma kinetics of MTX and 7-hydroxymethotrexate (7-OH-MTX) has been routinely monitored. Due to inadequate...

...S.H. Advani; A.R. Mehta; R.S. Rao; A.R. Fakih; V.D. Sanghvi; C.N. Nair; R. Gopal 200 mg/m 2 methotrexate given intravenously in a running drip for 6 h has been used as an initial adjuvant therapy in 38 patients with advanced head and neck cancer. The response rate is as high as 80%, with 21...

...S. Biran; G. Brufman 104 nonrandomized patients suffering from metastatic breast cancer were treated with monthly cycles of cyclophosphamide, methotrexate and 5-fluorouracil (CMF). One group (group A, 44 patients) received low-dose CMF and another one (group B, 60 patients) received standard doses...

...D.A. Decker; J.H. Edmonson; G.S. Gilchrist; J.S. Kovach; J.R. Offord; W.F. Taylor 23 patients with osteogenic sarcoma were observed during 142 6-hour high-dose infusions of methotrexate (MTX, 3,000–8,200 mg/m 2 ). Calcium leukovorin was given by intravenous injection at 3-hour intervals beginning 2...

...-propylamine platinum IV (CHIP), cis-diaminedichloroplatinum II (DDP), cyclophosphamide (CTX) and methotrexate (MTX). Nontreated tumor-bearing mice were observed to survive 43 + 7 days (mean + SEM) with an average tumor burden of 8.45 + 0.65 g (mean + SEM) of solid tumor tissue. Lung metastasis was observed...

... of arabinosylcytosine and of methotrexate are briefly discussed. The modulation of the action of an antimetabolite by a modification of the bioavailability of certain metabolites is mentioned as an approach towards the development of more selective chemotherapy. 10 6 2009 © 1980 S. Karger AG, Basel 1980...

...Nicholas J. DiBella; Roald A. Nelson; Michael J. Norgard 18 patients with metastatic or recurrent bronchogenic carcinoma and one patient with a squamous cell carcinoma of the trachea were treated with a combination of CCNU, hexamethylmelamine and methotrexate. Objective remissions were observed...

...Guillermo Ramirez; Jerome Klotz; J.G. Strawitz; W.L. Wilson; G.N. Cornell; R.E. Madden; J.P. Minton A randomized clinical trial, involving approximately 100 patients, that compared two combination therapy regimens (5 FU, methotrexate, vincristine, cyclophosphamide with and without prednisone...