... in the treatment of advanced endocrine tumors. Its potential toxicity would represent the main limiting factor for the clinical experiments with IL-2. Our previous studies have shown that the pineal hormone melatonin (MLT) may amplify the antitumor activity of IL-2, either through immunomodulating mechanisms...

... melatonin (MLT) in patients with glioblastoma treated with radical or adjuvant radiotherapy (RT). The study included 30 patients with glioblastoma, who were randomized to receive RT alone (60 Gy) or RT plus MLT (20 mg/daily orally) until disease progression. Both the survival curve and the percent...

... to decrease on IL-2 cancer therapy, and this side effect depends on the enhanced peripheral platelet destruction following the activation of the macrophage system by IL-2 itself. Our previous studies showed that IL-2-induced macrophage activation may be counteracted by the pineal hormone melatonin (MLT...

...P. Lissoni; S. Barni; G. Tancini; F. Rovelli; A. Ardizzoia; A. Conti; G.J.M. Maestroni The mechanisms responsible for the immunostimulatory role of the pineal hormone melatonin (MLT) are still obscure. To investigate the influence of MLT on interleukin-2 (IL-2)-induced immune effects in cancer, we...

...Christian Bartsch; Hella Bartsch; Anita Buchberger; Hartmut Rokos; Dieter Mecke; Theodor H. Lippert Nocturnal (23.00-07.00 h) urinary melatonin and total biopterin (tBI; after acidic oxidation of reduced biopterins) were analyzed during the growth of two passages of a mammary tumor line in female...

.... Our preliminary studies have shown that the pineal hormone melatonin may amplify IL-2 activity, which becomes active also at low doses in several tumor histotypes. On this basis, we have performed a clinical trial to evaluate the impact of low-dose IL-2 plus melatonin on the survival time...

...Paolo Lissoni; Sandro Barni; Marina Cazzaniga; Antonio Ardizzoia; Franco Rovelli; Fernando Brivio; Gabriele Tancini Our preliminary studies in humans have shown that the pineal neurohormone melatonin (MLT) may enhance the antitumor activity of IL-2, by confirming the existence of a neuroendocrine...

...P. Lissoni; S. Barni; G. Cattaneo; G. Tancini; G. Esposti; D. Esposti; F. Fraschini The pineal hormone melatonin (MLT) is able to exert an oncostatic action. Its possible use in the treatment of human tumors, however, has not yet been investigated. The present study was carried out to evaluate...

...Geoffrey Falkson; Hentirè C. Falkson; Maria E. Steyn; Bernardo L. Rapoport; Bern J. Meyer Daytime plasma melatonin values were measured by radioimmune assay in 86 patients with breast cancer; 280 assays were done and compared with the clinical status of the patients. Patients in the advanced...

...H. Bartsch; C. Bartsch; W.E. Simon; B. Flehmig; I. Ebels; T.H. Lippert There is growing evidence that the pineal gland has antineoplastic properties which, however, can only partially be attributed to its hormone melatonin. While the in vivo tumor-inhibiting activity of melatonin is established...

... system, the pineal hormone, melatonin, seems to play an important antineoplastic role. To investigate its secretion in relation to tumor growth, we have evaluated the daily serum levels of melatonin in a group of 25 untreated breast cancer patients with a locally limited disease. Tumor cell proliferation...

... containing cisplatin. Since recent data have demonstrated the antineoplastic properties and the lack of toxicity of the pineal hormone melatonin (MLT), a randomized study was designed to evaluate the influence of an MLT treatment (10 mg/day orally at 7.00 p.m.) on the survival time at 1 year from...

...Lalita Shirish Kothari Daily treatment of ‘functionally’ and surgically pinealectomized female Holtzman rats reared in continuous light (light: dark schedule, 24L:OD) with oral melatonin (100 pig/day/rat) initiated 30 days prior to and 90 days following 9,10-dimethyl-1,2-benzanthracene (DMBA...

...V. Lapin; I. Ebels With these preliminary experiments attention is drawn to a possible relation between tumor development and the pineal. The influence of melatonin and some low molecular weight pineal fractions on the growth and incidence of different experimental tumors was compared. Some pineal...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Breast cancer Electromagnetic fields Melatonin 7,12-Dimethylbenz[a]anthracene...

...Christian Bartsch; Hella Bartsch; Anita Buchberger; Ariane Stieglitz; Anja Effenberger-Klein; Jürgen D. Kruse-Jarres; Ingo Besenthal; Hartmut Rokos; Dieter Mecke Previous studies on human breast cancer patients showed a decline in circulating melatonin levels corresponding to primary tumor growth...