..., we aimed to establish an integrated profile of genetic and epigenetic alterations in HER2-positive BC by using tissue samples obtained from a neoadjuvant clinical trial. We have conducted a trial to determine if neoadjuvant chemotherapy can be optimized by using the Ki-67 index changes...

..., instructions or products referred to in the content or advertisements. Ki-67 CS-IHC4 Hormone receptor Human epidermal growth factor receptor 2 Nomogram Breast cancer is the most common cancer among women throughout the world. About 13 million women are diagnosed with breast cancer each year...

... as strong positive. FOXP3-positive tumors were associated with significantly higher nuclear grade, higher histologic grade and a more negative estrogen receptor status. The FOXP3 expression level was independently associated with high Ki-67 index in a logistic regression model. In the node-positive subgroup...

...-year cumulative disease-free survival rate was 79.5%, and the recurrence rate at ≥10 years was 5.8%. A multivariate analysis revealed that the factors related to late recurrence were PgR positivity and positive nodes. This result differed from that for early recurrence in terms of ER/PgR, Ki-67 index...

...Nobuaki Matsubara; Hirofumi Mukai; Kuniaki Itoh; Shunji Nagai Background: Ki-67 overexpression has been reported to be related to a poor prognosis for early stage breast cancer. We analyzed whether Ki-67 has a prognostic impact on risk subgroups based on the recommendations at St. Gallen in 2007...

...L. Miglietta; P. Vanella; L. Canobbio; C. Naso; N. Cerisola; P. Meszaros; M.A. Parodi; F. Morabito Purpose: Breast cancers expressing high levels of Ki-67, a nuclear marker of cell proliferation, are associated with worse outcome. Recent data from neoadjuvant studies indicate that a single...

...M. Victorzon; P.J. Roberts; C. Haglund; K. von Boguslawsky; S. Nordling Expression of the Ki-67 antigen was determined by immunohistochemical analysis of paraffin-embedded specimens from 242 patients with gastric adenocarcinoma and the prognostic value of Ki-67 immunoreactivity was compared...

.... Immunohistochemical staining with anti-Ki-67 monoclonal antibody MIB-1 was performed for 22 HCCs to assess proliferative activity. Tumor tissues expressed Pgp on the biliary surface and on the luminal surface of cancer cells, which was less extensive than in normal and cirrhotic liver hepatocytes. Expression of Pgp...

... the proliferative activity of cancer cells by immunostaining with the Ki-67 monoclonal antibody in 95 cases of surgically resected esophageal squamous cell carcinoma and compared them with the extent of lymphocytic infiltration of the tumor (LI) in the same specimens. The mean Ki-67 score of 43 tumors with low...

... was established by measuring Ki-67 labeling rate. As controls, 46 healthy women were considered. Breast cancer patients showed significantly higher mean values of melatonin than controls. Moreover, patients with negative Ki-67 labeling rate had significantly higher levels of the pineal hormone than those...

...Kohsuke Sasaki; Kouji Matsumura; Tomoyuki Murakami; Tatsuo Tsuji Nuclear DNA content and three cell proliferation markers, the bromodeoxyuridine (BrdUrd) labeling index, Ki-67 score and Ag-nucleolar organizer region (Ag-NOR) counts, were measured in 21 cases of breast carcinoma...

...), including the cell cycle-related proteins (p27, cyclin D1, 14-3-3σ, p53, cyclin B1 and Ki-67), the proto-oncogenes (c-erbB-2 and c-Met), the extracellular matrix proteins (tenascin and laminin) and others (β-catenin, epidermal growth factor receptor, osteopontin, aquaporin 1, MUC5AC and fascin...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. GnT-V Carcinogenesis Esophageal cancer L4-PHA Ki-67 The prognosis for esophageal carcinoma remains poor...

... immunohistochemically with a labeled streptavidin-biotin kit using anti-Glut1 polyclonal antibody MYM. As a marker of cell proliferation, Ki-67 expression was also examined. All immunoreactivity was analyzed at the deepest invasive site, central portion and superficial part. The immunohistochemical expression of Glut1...

... pathologial markers of clinical aggressiveness were retrospectively investigated: p53 and Ki-67 expression were determined by means of immunohistochemistry. Angiogenesis was assessed by determination of intratumor microvessel density at the vascular ‘hot spot’ with the anti-CD34 monoclonal antibody...

...: Fifty rectal carcinoid tumors were studied clinicopathologically and experimentally. Expression of Ki-67, TGF-α, p53, and bcl-2 was examined immunohistochemically, and apoptotic cells were identified by the in situ DNA nick end labeling method. EGF receptor expression was examined by a colorimetric...

... stage, portal invasion, intrahepatic metastasis, poor differentiation, high α-fetoprotein level, large size, high Ki-67 labeling index and poor prognosis. Cyclin A and B1 overexpression showed similar tendency to that of cdc2, but they were not recognized as independent prognostic factors...

... and progression is unclear. We studied the relationship between MUC1 expression in intramucosal CRC and clinicopathologic features, expression of Ki-67, and p53 protein, and apoptosis. Methods: The intramucosal CRC we studied included 140 endoscopically or surgically resected lesions, including 106 low-grade...