..., interferon, and nivolumab for the treatment of relapsed, refractory, metastatic, or unresectable FLC. Methods: Data from all patients who received TT from May 2018 to July 2020 were reviewed to assess response, survival, and toxicity. Results: A total of 22 patients were treated with TT, of which 14 (median...

... eradication of hepatitis C virus (HCV) RNA by antiviral therapy with direct-acting antivirals are unknown. Especially the impact of treatment with or without interferon on hepatocarcinogenesis is not clear. Methods: A total of 958 patients with HCV genotype 1-related chronic liver disease and a sustained...

... virus (HCV)-related cirrhosis. Patients and Methods: We analyzed stepwise progression rates from cirrhosis to hepatocellular carcinoma (HCC) and to death using a Markov model in 1,280 patients with HCV-related cirrhosis. During the observation period, 303 patients received interferon and 736 received...

...Satoru Aoyagi; Hiroo Hata; Erina Homma; Hiroshi Shimizu Objective: To determine the beneficial effect of maintenance therapy in stage II and III melanoma by sequential local injection of low-dose interferon-β. Methods: We reviewed 46 patients with stage II and III primary melanoma at our...

...Tatsuya Yamashita; Kuniaki Arai; Hajime Sunagozaka; Teruyuki Ueda; Takeshi Terashima; Taro Yamashita; Eishiro Mizukoshi; Akito Sakai; Yasunari Nakamoto; Masao Honda; Shuichi Kaneko Objective: This randomized phase II trial compared the response rates to treatment with interferon (IFN) combined...

...Hiroaki Nagano; Hiroshi Wada; Shogo Kobayashi; Shigeru Marubashi; Hidetoshi Eguchi; Masahiro Tanemura; Yoshito Tomimaru; Keigo Osuga; Koji Umeshita; Yuichiro Doki; Masaki Mori Background/Aim: We previously reported the beneficial effects of a combination therapy of interferon (IFN)-α/5-fluorouracil...

... therapy for HCC and it is not difficult to maintain; but the effective rate is not sufficient. Recently, the combination therapy of subcutaneous interferon (IFN)-α and intraarterial 5-fluorouracil (5-FU) showed an outstanding response rate for intractable HCC (with portal vein thrombosis). In addition...

...Cristina Noberasco; Gianluca Spitaleri; Patrizia Mancuso; Laura Zorzino; Davide Radice; Alessandra Milani; Andrea Rocca; Francesco Bertolini; Maria Teresa Sandri; Giuseppe Curigliano; Tommaso de Pas; Costantino Jemos; Emanuela Omodeo Salè; Sabrina Boselli; Filippo de Braud Background: α-Interferon...

...Akio Urabe Interferon (IFN) has diverse acitvities against the proliferation and function of various tumor cells. Recently, IFN-α has been widely used in the treatment of several hematological malignancies including chronic myelogenous leukemia (CML), multiple myeloma, and hairy cell leukemia. IFN...

...) with folinic acid (FA) resulted in an improved response rate and survival in the responder patients. Preclinical studies also showed an enhancement of FU and anthracyclines with interferon. To evaluate the possibility of human lymphoblastoid interferon (IFN) to enhance the therapeutic activity of the FA-FU...

...I. Tamm; H. Grimme; E. Bergen; J.C. Simon; E. Schöpf; R. Mertelsmann; A. Lindemann; U. Brennscheidt Based on encouraging reports of improved response rates with the use of dacarbazine (DTIC) in combination with recombinant interferon alpha-2a (rIFN-α-2a) in patients with metastatic malignant...

... with metastatic colorectal cancer compared to 5-FU alone. Phase II trials also demonstrated increased efficacy when interferon was added to 5-FU. In two consecutive trials, 76 patients were treated on days 1-5 with FA 200 mg/m 2 plus interferon 5 × 10 6 U/m 2 and 5-FU 350 mg/m 2 as intravenous bolus injection (n...

...Fumimaro Takaku As the introduction to a special issue of Oncology on the role of cytokines for cancer treatment, this article summarizes their various current uses. Interferons, interleukin-2 and hematopoietic factors are extensively used for the treatment of hematopoietic as well...

... (IL-2) and β-interferon (β-IFN), 15 patients with colorectal cancer and 10 patients with hepatocellular carcinoma were treated with the following outpatient schedule: β-IFN 3 × 10 6 U i.m. 3 times weekly from day 1 to day 14; IL-2 4.5 × 10 6 U s.c. every 12 for 5 consecutive days a week from day 7...

... of approach in the treatment of cancer. The in vitro antitumor activities of these agents, such as interferons, when combined with chemo- or radiotherapy, have generated enthusiasm among clinicians for developing clinical trials. In recent years many antineoplastic agents have been investigated as neoadjuvant...

...Kayoko Nakamura; Atsushi Kubo; Saiko Hosokawa; Kazuhiro Nagaike; Shozo Hashimoto We studied the potential of alpha-interferon(IFN-Α) to enhance alpha-feto-protein (AFP) and thus alter the localization of 125 I-labeled antibody to the human hepatoma xenograft in athymic mice using monoclonal...

...Igor A. Mikhalkin; Zakhar G. Iashvili; Vladimir L. Bykov For the prophylaxis of head and neck cancer recurrence and metastases we used radiation therapy, microwave hyperthermia and adjuvant therapy (inhibitor of proteolysis contrical and α-interferon). One hundred forty patients with primary cancer...

... cytotoxicity (ADCC) of these patients, on chicken red blood cells as targets, was within normal range. In this paper, we have attempted to modulate the NK cytotoxicity of CML patients in remission with interferon (IFN) and interleukin-2 (IL-2) singly or together. ADCC using K562 target-directed monoclonal...

...Sau C. Cheung; Donald E. Nerland; Gerald Sonnenfeld Murine L-929 cells were treated with benzene or a series of benzene metabolites, washed and then interferon-α/β was induced with polyriboinosinic-polyribocytidylic acid. Exposure of the cells to benzene or phenol, a monocyclic metabolite...

...Tariq I. Mughal; Roy Thomas; William A. Robinson A total of 65 patients with advanced cutaneous malignant melanoma (MM) have now been treated with interferon alpha-2b (Intron A) at a dose of 10 million IU/m 2 administered subcutaneously thrice weekly. Fifty-one patients were evaluable for response...