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Keywords: Hypoxia
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Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (1987) 44 (6): 386–391.
Published Online: 23 June 2009
... was given by intraperitoneal injection to the tumor-bearing mouse and cell survival was measured by excision assay. For the KHT tumor, hypoxic cells were found to be more sensitive to the drug in vivo than were aerated cells, and a similar response to hypoxia was observed in vitro, suggesting...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2008) 75 (Suppl. 1): 17–21.
Published Online: 17 December 2008
...Jung-Hwan Yoon; Hyo-Suk Lee Hepatocellular carcinoma (HCC) is characteristically hypervascular, and therefore many antiangiogenic therapies are under clinical investigation. However, their therapeutic efficacies are still limited. While inhibition of angiogenesis results in tumor hypoxia and cell...
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2005) 69 (Suppl. 3): 4–10.
Published Online: 23 November 2005
... are expressed on vascular endothelial cells. In healthy humans, VEGF promotes angiogenesis in embryonic development and is important in wound healing in adults. VEGF is the key mediator of angiogenesis in cancer, in which it is up-regulated by oncogene expression, a variety of growth factors and also hypoxia...
Journal Articles
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2002) 63 (Suppl. 2): 11–18.
Published Online: 13 December 2002
... the oxygen-carrying capacity of the blood, anemia may result in tumor hypoxia and may have a negative influence on the outcome of radiotherapy for various malignancies, even for small tumors not normally assumed to be hypoxic. In addition, anemia also has a negative effect on the quality of life of cancer...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2002) 63 (Suppl. 2): 19–28.
Published Online: 13 December 2002
... further elucidation. It is postulated that lower hemoglobin levels resulting in decreased oxygen carrying capacity may lead to increased tumor hypoxia, radiation resistance and increased tumor angiogenesis. The interrelationship of low hemoglobin levels, hypoxia, tumor angiogenesis and survival...
Journal Articles
Subject Area:
Oncology
Journal: Oncology
Oncology (2000) 58 (2): 175–182.
Published Online: 23 February 2000
... radiotherapy. Further, the means to manipulate the hemoglobin level, their indication and administration need to be clarified. Available experimental and clinical data on hypoxia, anemia and on their treatment with erythropoietin have been extensively discussed at an international conference in Freiburg...